BACKGROUND The oriental river prawn, Macrobrachium nipponense, is an important aquaculture species in China, even in whole of Asia. The androgenic gland produces hormones that play crucial roles in sexual differentiation to maleness. This study is the first de novo M. nipponense transcriptome analysis using cDNA prepared from mRNA isolated from the androgenic gland. Illumina/Solexa was used for...

The course of rnammalian sexual differentiation is largely under the control of the principal male gonadal steroid, the androgen testosterone. Despite the importance of androgens in the rnediation of sexual differentiation, the molecular basis of androgenic activity in the central nervous system remains poorly characterized. Calcitonin gene-related peptide (CGRP) has previously been reported to...

The anabolic-androgenic steroids (AAS) are a family of hormones that includes testosterone and its derivatives. These substances have been used by elite athletes since the 1950s, but they did not become widespread drugs of abuse in the general population until the 1980s. Thus, knowledge of the medical and behavioral effects of illicit AAS use is still evolving. Surveys suggest that many million...

Anabolic-androgenic steroids (AASs) are used as performance enhancement and widely utilized among athletes non-athletes worldwide. Although the risk-benefit ratio of using Performance Enhancing Drugs (PEDs) explicitly primarily published systematic reviews post-mortem case reports, there limited reports on effects PEDs body mass index, blood pressure, sugar levels.

Therapy based on androgenic deprivation is one of the standard treatments that many prostate cancer patients receive. Moreover, its use is increasing owing to a clear expansion of the indications for this therapy in patients with localized prostate cancer. Despite classically being considered to be well tolerated, androgenic deprivation has adverse effects. Of these, the loss of mineral bone ma...

Prostate-specific antigen (PSA) is the most sensitive marker available for monitoring the progression of prostate cancer and response to therapy. In a previous study, we demonstrated tissue-specific expression of PSA glycoprotein and mRNA and its regulation through the androgen receptor. In this study, we examine the effects of protein kinase A (PKA) and protein kinase C (PKC) on the androgen r...