Systemic blood pressure is regulated by 3 mechanisms: the sympathetic nervous system, the renin-angiotensin system, and the arginine-vasopressin system. The use of angiotensin II receptor blockers and angiotensin-converting enzyme inhibitors has become prevalent in the medical treatment of hypertension. These classes of medications inhibit the renin-angiotensin-aldosterone system, specifically ...

The octapeptide hormone angiotensin II is one of the most studied peptides with aim designing and synthesizing non-peptide mimetics for oral administration. To achieve this, cyclizations at different positions within peptide molecule has been a useful strategy to define active conformation. These studies on led discovery Sarmesin, type antagonist, breakthrough mimetic Losartan, first in series ...