Discoveries in the physiology of immunology have increased at an increasing rate during the past two decades. It is now recognized that the immune system is just another physiological system that regulates, and is regulated by, other physiological systems such as the brain. These advances make it clear that recent findings in genomic biology must be interpreted in the context of the environment...

The effects of various amounts of thyrotropin-releasing hormone (TRH) injected subcutaneously or intravenously (alone or in combination with growth hormone-releasing factor: GRF 1-44) on growth hormone (GH), thyroid-stimulating hormone (TSH), thyroxine (T4) and triiodothyronine (T3) were studied in the plasma of 2-week, 2-month and 3-month old lambs. After subcutaneous TRH administration, incre...

the aim of this study was to investigate the potential association between growth hormone gh/alui and growth hormone receptor ghr/alui polymorphisms with milk yield and reproductive performances in holstein dairy cows in iran. blood samples of 150 holstein cows were collected and their genomic dna was extracted using gene-fanavaran dna extracting kit. fragments of the 428 bp of exon 5 growth ho...

Resistance to growth hormone, reduced insulin-like growth factor 1 (IGF1) action, and enhanced insulin sensitivity are likely mediators of extended life span and delayed aging process in growth hormone receptor/binding protein knockout (GHR-KO) mice. Fat metabolism and genes involved in fatty acid oxidation are strongly involved in insulin action. Using real-time polymerase chain reaction and w...

Various central nervous system (CNS) tissues express both growth hormone (GH) and its receptor (GHR), including those involved in memory and cognition. Studies show the presence of GHR in the pituitary, choroid plexus, hypothalamus, hippocampus, pituitary and the spinal cord during development and, to a lesser extent, in adults. This expression implies a role of GH signaling in growth, developm...

Thyroid hormones are essential for skeletal development and are important regulators of bone maintenance in adults. Childhood hypothyroidism causes delayed skeletal development, retarded linear growth and impaired bone mineral accrual. Epiphyseal dysgenesis is evidenced by classic features of stippled epiphyses on X-ray. In severe cases, post-natal growth arrest results in a complex skeletal dy...

The administration of pituitary growth hor mone (STH) to C3H mice bearing transplanted mammary adenocarcinoma has been shown to cause an increase in the tumor and animal weights when the mice were sacrificed at the end of a 27day injection period (5). It was also observed that the animals receiving STH appeared generally healthier than did their respective controls at the time they were sacrifi...