We have previously described a noncytotoxic lymphokine, tumor migration inhibition factor, with the capacity of inhibiting the in vitro migration of a variety of tumor cells maintained by animal passage in ascitic form. In the present study, we dem onstrate that it is possible to prepare viable, motile tumor cell suspensions from solid tumors and that those cells migrate better than cells that ...

A challenge in animal ecology is to link animal movement to demography. In general, reproducing and non-reproducing animals may show different movement patterns. Dramatic changes in reproductive status, such as the loss of an offspring during the course of migration, might also affect movement. Studies linking movement speed to reproductive status require individual monitoring of life-history e...

Clostridium difficile is an important bacterial pathogen of humans and a variety of animal species, where it can cause significant medical problems. The major public health concern is the possibility of inapparent animal reservoirs of C. difficile and shedding of bacteria to noninfected individuals or populations, as well as being a source of food contamination. Migrating birds can be a key epi...

Several antagonists specific for platelet-derived growth factor (PDGF) or its receptors have recently been developed and shown to inhibit intimal hyperplasia formation in various animal models, but data investigating the durability of this intervention is limited. The present study was designed to investigate the potency of PDGF B-chain aptamer, a novel type of PDGF-AB and -BB antagonist, in th...

Our work tackles collective motion and decision-making in a primitive multicellular animal, Trichoplax adhaerens, enabling pioneering research into how intercellular coordination affects animal behavior and how migration accuracy scales with group size. Collective motion of cells is critical to some of the most vital tasks including wound healing, development, and immune response [Friedl and Gi...

Cell migration is fundamental in both animal morphogenesis and disease. The migration of individual cells is relatively well-studied; however, in vivo, cells often remain joined by cell-cell junctions and migrate in cohesive groups. How such groups of cells coordinate their migration is poorly understood. The planar polarity pathway coordinates the polarity of non-migrating cells in epithelial ...

Using data from two post-frontier rural settings, Nang Rong, Thailand (N=2,538) and Chitwan Valley, Nepal (N=876), this paper examines agricultural push factors determining the outmigration of young people age 15 to 19. We focus on different dimensions of migration, including distance and duration. Our study examines a wide array of agricultural determinants, each with its own potential effect ...

BACKGROUND Glycolysis machinery regulates cancer cell behavior. However, the roles of these glycolysis enzymes in oral squamous cell carcinoma (OSCC) progression remain unknown. METHODS Fructose-bisphosphate aldolase C (ALDOC) expression in OSCC patients and cell lines was detected using quantitative real-time polymerase chain reaction (PCR). The functions of ALDOC in migration and invasion w...

of Dissertation Presented to the Graduate School of the University of Florida in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy NEW MODELS OF ANIMAL MOVEMENT By Andrew M. Hein August 2013 Chair: James F. Gillooly Cochair: Scott A. McKinley Major: Zoology Movement is an iconic feature of life; microorganisms swim up chemical gradients, motile predators search thei...