Childhood obesity has increased dramatically in the United States during the past 30 years, which has been associated with a parallel rise in systolic blood pressure (BP) and pulse pressure (PP) in adolescents and young adults. Consistent with the elevation in systolic BP and PP, there has been an increase in the rates of prehypertension and hypertension mostly in youth with obesity, with the m...

BACKGROUND Although the aortic augmentation index (AI) is an attractive tool as an index of the vascular system, the association between radial AI or brachial-ankle pulse wave velocity (PWV) and severity of atheroma or arterial stiffness of the morphological central artery is unclear. METHODS AND RESULTS Severity of atheroma and aortic stiffness of the descending thoracic aorta (DTA) by trans...

BACKGROUND The SCORE system is a simple, currently recommended method of cardiovascular risk assessment. The aim of this study is to determine the relationship between SCORE risk and intima media thickness (IMT) and flow mediated dilatation (FMD) in a low risk population. METHODS 119 people (59 men) without known cardiovascular disease and estimated by means of SCORE system risk < 5%, were in...

The brachial artery is rarely injured in closed posterior dislocation of the elbow, unlike the high rate of vascular injury seen after dislocation of the knee. Despite the anatomical proximity of the brachial artery to the elbow joint, most cases of brachial artery injury after dislocation of the elbow are related to an associated fracture, an open injury or high-energy trauma. A high index of ...

BACKGROUND There is a need to identify sensitive biomarkers of early tobacco-related cardiovascular disease. We examined the association of smoking status, burden, time since quitting, and intensity, with markers of inflammation and subclinical atherosclerosis. METHODS AND RESULTS We studied 14 103 participants without clinical cardiovascular disease in ELSA-Brasil (Brazilian Longitudinal Stu...

BACKGROUND Cadmium has been associated with peripheral arterial disease (PAD) in cross-sectional studies, but prospective evidence is lacking. Our goal was to evaluate the association of urine cadmium concentrations with incident PAD in a large population-based cohort. METHODS AND RESULTS A prospective cohort study was performed with 2864 adult American Indians 45 to 74 years of age from Ariz...