OBJECTIVE To determine the per patient and overall cost of illness of type 2 diabetes mellitus (T2DM) in Colombia from Ministry of Health and societal perspectives. METHODS A published Markov transition model was adapted for Colombia, using the clinical expertise of a Colombian endocrinologist. Transition probabilities for the model were derived from an international literature review. A mode...

improper drug prescription by physicians due to wrong diagnosis, wrong drug choise or other causes will waste national funds. the annual drug costs in iran is 900 billions rials. with approvement of prescription, it can be reduced to 500 billions rials. effective factors in costs reduction are: 1) increasing medical knowledge and persistent education of physicians. 2) spending more time for eac...

This paper presenting case studies in modern large scale constrained optimization, the purpose of which is to illustrate how recent advances in algorithms and modelling languages have made it easy to solve difficult optimization problems using of software. In this paper we use measure theory technique and iterative dynamic programming algorithm for solving of a trajectory optimization problem: ...

Simulated annealing is a multivariable optimization technique based on the Monte Carlo method used in statistical mechanical studies of condensed systems and follows by drawing an analogy between energy minimization in physical systems and costs minimization in design applications. In this paper, simulated annealing is introduced and reviewed. The utility of the method for optimization of chemi...

BACKGROUND Costs and benefits of two Salmonella control policies for broiler production were described and compared. The control options were the Zoonosis Directive 92/117/EC and the more intense strategy, the Finnish Salmonella Control Programme (FSCP). METHODS The comparison included the Salmonella control costs in primary and secondary production and the direct and indirect losses due to S...

BACKGROUND Data on the economic burden of head and neck cancers (HNCs) in Germany is scarce. About 16%-28% of these cancers are associated with human papillomavirus (HPV) infection. Therefore, the study reported here aimed to assess the annual costs of HPV-related HNCs incurred by hospitalization, inpatient rehabilitation, and sick leave in Germany in 2008. METHODS A cross-sectional retrospec...