UNLABELLED BACKGROUND Cholesterol is an important membrane component, but our knowledge about its transport in cells is sparse. Previous imaging studies using dehydroergosterol (DHE), an intrinsically fluorescent sterol from yeast, have established that vesicular and non-vesicular transport modes contribute to sterol trafficking from the plasma membrane. Significant photobleaching, however, ...

Living organisms can sense extracellular forces via mechanosensitive ion channels, which change their channel conformations in response to external pressure and regulate transport through the cell membrane. Such pressure-regulated is critical for various biological processes, such as cellular turgor control hearing mammals, but has yet be achieved artificial systems using similar mechanisms. In...

We study transport in an idealized porous medium characterized by a spatially varying retardation factor, which models linear instantaneous chemical adsorption of a solute. Using a stochastic modelling approach, we study the impact of disorder correlation on the large-scale dispersion behaviour. We consider short, long-range and intermediate-range disorder correlations, and demonstrate that (tr...