A doença de Alzheimer se caracteriza por ser uma neurodegenerativa, com um declínio progressivo funções cognitivas e motoras. Devido a esse quadro irreversível apresentar deterioração progressiva, tem efeitos devastadores nos portadores seus familiares. Este trabalho foi desenvolvido o objetivo analisar na literatura os impactos, desafios as atribuições da enfermagem durante processo cuidar vid...

BACKGROUND Alzheimer's disease (AD) is the most common neurodegenerative disorder, neuropathologically characterized by aggregates of β-amyloid peptides, which deposit as senile plaques, and of TAU protein, which forms neurofibrillary tangles. It is now widely accepted that neuroinflammation is implicated in AD pathogenesis. METHOD Indeed, inflammatory mediators, such as cytokines and chemoki...

Multitarget compounds are increasingly being pursued for the effective treatment of complex diseases. Herein, we describe the design and synthesis of a novel class of shogaol-huprine hybrids, purported to hit several key targets involved in Alzheimer's disease. The hybrids have been tested in vitro for their inhibitory activity against human acetylcholinesterase and butyrylcholinesterase and an...

Alzheimer disease is the most common cause of dementia among the elderly, accounting for ~60-70% of all cases of dementia. The neuropathological hallmarks of Alzheimer disease are senile plaques (mainly containing p-amyloid peptide derived from amyloid precursor protein) and neurofibrillary tangles (containing hyperphosphorylated Tau protein), along with neuronal loss. At present there is no ef...

Saffron or Crocus sativus L. (C. sativus) has been widely used as a medicinal plant to promote human health, especially in Asia. The main components of saffron are crocin, picrocrocin and safranal. The median lethal doses (LD50) of C. sativus are 200 mg/ml and 20.7 g/kg in vitro and in animal studies, respectively. Saffron has been suggested to be effective in the treatment of a wide range of d...

Zusammenfassung Die Alzheimer-Demenz ist die häufigste Demenzform und zählt zu den neurodegenerativen Erkrankungen. Im Verlauf kommt es bei Betroffenen einer zunehmenden kognitiven Verschlechterung mit damit einhergehender Einschränkung von Alltagskompetenz Veränderung der Persönlichkeit. Typische Symptome Beginn sind unter anderem Gedächtnisprobleme, Orientierungslosigkeit, Schwierigkeiten Spr...

Objective(s): Alzheimer’s disease (AD) as progressive cognitive decline and the most common form of dementia is due to degeneration of the cholinergic neurons in the brain. Therefore, administration of the acetylcholinesterase (AChE) inhibitors such as donepezil is the first choice for treatment of the AD. In the present study, we focused on the synthesis and anti-cholinesterase evaluation of n...

The extent of microbial community diversity in two similar sandy surface soils from Virginia and Delaware (USA) was analysed with a culture-independent small subunit ribosomal RNA (SSU rRNA) gene-based cloning approach with about 400–700 SSU rDNA clones obtained from each sample. While there were no operational taxonomic units (OTUs) having more than three individuals, about 96–99% of the OTUs ...

Alzheimer disease and type 2 diabetes are characterized by increased prevalence with aging, a genetic predisposition, and comparable pathological features in the islet and brain (amyloid derived from amyloid beta protein in the brain in Alzheimer disease and islet amyloid derived from islet amyloid polypeptide in the pancreas in type 2 diabetes). Evidence is growing to link precursors of amyloi...