interaction between urokinase-type plasminogen activator (upa) and its receptor (upar) plays an important role in the progression of numerous cancer types including breast cancer by promoting tumor initiating,  proliferation,  invasion  and  metastasis.  hence,  disruption  of  this  interaction  inhibits  their downstream cascades and subsequently tumor growth. for this, we created two series ...

female cancer, especially breast and gynecologic cancers are considered multistage disease, highly influenced by risk and protective factors and/or screening preventive modalities. consequences of all these factors result in the trend of change over time.in this comparative study, based on data of national cancer registry of iran 2004 published by iranian ministry of health, age - standard inci...

Cancer remains to be a major global healthcare burden as 18.1 million new cases and 96 death occurred 2018 on the basis of report from international agency for research cancer Breast is most common diagnosed in women causing highest morbidity. Ipomoea carnea leaf extracts have been used chemotherapeutic agent due their antioxidant, anti-inflammatory, anti-bacterial, anti-tumor effect. The aim s...

background: lactating adenoma is a benign breast mass related to physiological changes during pregnancy and increased estrogen level. fibroadenoma and breast cancer should be considered in the differential diagnosis of this lesion. the purpose of this study was to report cases of lactating adenoma in breast cancer research center (bcrc) and review the relevant literature. methods: all patients ...

Purpose: Novel therapeutic targets of estrogen receptor (ER)– positive breast cancers are urgently needed because current antiestrogen therapy causes severe adverse effects, nearly 50% of patients are intrinsically resistant, and the majority of recurrences have maintained ER expression. We investigated the role of estrogen-dependent chemokine expression and subsequent cancer growth in human ti...

Reports suggest that metformin, a popular anti-diabetes drug, prevents breast cancer through various systemic effects, including insulin-like growth factor receptor (IGFR) regulation. Although the anti-cancer properties of metformin have been well-studied, reports on a more bioavailable/potent biguanide, phenformin, remain sparse. Phenformin exerts similar functional activity to metformin and h...

One of the main components Pomegranate Seed Oil is punicic acid, an omega-5 fatty acid that capable inhibiting breast and prostate cancer cell proliferation, although mechanisms action are not yet known. In order to further understand its potential anti-cancer properties, we investigated effect on proliferation cytotoxicity human MCF-7 cells.

spirulina is free-floating filamentous microalgae growing in alkaline water bodies. as early as over 400 years ago, spirulina was eaten as food by the mayas, toltec’s and kanembu in mexico during the aztec civilization. spirulina is a well-known source of valuable food supplements, such as proteins, vitamins, amino acids, minerals, fatty acids, etc. it is widely used in human and animal nutriti...

nigella sativa has attracted healers in ancient civilizations and researchers in recent times. traditionally, it has been used in different forms to treat many diseases including asthma, hypertension, diabetes, inflammation, cough, bronchitis, headache, eczema, fever, dizziness and influenza. experimentally, it has been demonstrated that n. sativa extracts and the main constituent of their vola...