F(ab')2 fragments of rabbit anti-mouse Ig induce proliferation of murine B lymphocytes, whereas the intact antibodies are not mitogenic. F(ab')2 anti-Ig stimulates the rapid breakdown of inositol phospholipids in B cells, resulting in the prolonged release of inositol (poly)phosphates and diacylglycerol. In marked contrast, intact anti-Ig initially induces a comparable response, which is abroga...

graves’ disease is an autoimmune disorder characterized by presence of antibodies directed against thyroid stimulating hormone (tsh) receptor or nearby region. other serological abnormalities like antibodies to double stranded dna (ds–dna) and antinuclear antibodies (ana) have also been observed. we studied antibodies to ds-dna and ana in our patients with graves’ disease and compared them with...

the presence of anti-sperm antibodies (asa) in semen or serum may impair sperm function leading to immunological infertility. the aim of this study was to investigate the presence of asa on the surface of sperm and in circulating blood of infertile couples. in this cross sectional study, we studied 49 couples suffering from infertility for at least one year. serum asa (igg and iga classes) was ...

OBJECTIVE To determine whether high levels of antibodies against the phospholipid beta2-glycoprotein I (beta2-gpI) cofactor are associated with an increase in the risk of acute myocardial infarction. METHODS The study comprised 82 patients with acute myocardial infarction and 82 controls, who were assessed in regard to age, sex, race, hypertension, smoking, previous heart disease, history of ...

conclusions the present findings reveal a relatively high presence of anti-hev iggs and clearly indicate that hev infection is still present in northern algeria. further, the prediction of hev genotype using different antigens generated from the different hev genotypes shows that the causative strains are more likely to be of genotype 1. background two hepatitis e virus (hev) outbreaks occurred...

Anti-phospholipid antibodies (APA) like anti-cardiolipin antibodies (ACA) and anti-β2glycoprotien (anti-β2 GP) are important cause of venous and arterial thrombosis and other occlusive vascular diseases. The prevalence of these antibodies in SLE patients at the time of diagnosis is not known in Indian SLE patients. This study was conducted to evaluate the prevalence of ACA and anti-β2 GP autoan...

Background: Because of the inflammation boosting cytokines, Coronavirus disease 2019 (COVID-19) has demonstrated thrombotic consequences that have increased its morbidity and mortality. There is evidence mechanisms contribute in thrombosis COVID-19 patients are similar to those anti-phospholipid syndrome (aPS). In fact, there a possibility autoantibodies (aPLs) might impulse with COVID-19, as l...

Antiphospholipid antibodies (aPLs) are a heterogeneous group of antibodies directed against phospholipids or protein/phospholipid complexes. Currently, aPLs are assessed using either "solid-phase" assays that identify anticardiolipin antibodies and anti-β2-glycoprotein I antibodies or "liquid-phase" assay that identifies lupus anticoagulant. However, in the last few years, "new" antigenic targe...