نتایج جستجو برای: anti thymocyte globulin
تعداد نتایج: 379907 فیلتر نتایج به سال:
Thy-1 is a highly abundant glycoprotein on the surface of thymocytes and neurons. A null mutation in the gene encoding Thy-1 deregulates T-cell receptor signaling and causes abnormal thymocyte development; does this mean that Thy-1 has a signaling function?
B16 mouse melanoma cells (clone BS59) grown in 1 to 3 ¿ig of 5-bromodeoxyuridine (BUdR) per ml form few or no tumors in C57BL/6J adult mice when injected subcutaneously in doses at which untreated cells always form tumors. Injections of BUdR-grown cells protect adult mice against melanoma. Melanoma cells grown in 1/ig of BUdR per ml for almost 1 year (clone C3471) retain a plating efficiency s...
A type-C RNA virus has been isolated that replicates readily in human and other primate cells. It was obtained from a human rhabdomyosarcoma cell (RD) that had been serially transplanted in immunosuppressed NIH Swiss mice, a strain of mouse from which infectious type-C virus has not been isolated. Various other human tumor cells, similarly transplanted, remained free of overt type-C virus expre...
AUTOPHAGY-RELATED PROTEIN (ATG) 8-FAMILY INTERACTING MOTIF IN ATG3 MEDIATES THE ATG3-ATG8 INTERACTION AND IS CRUCIAL FOR THE CYTOPLASM-TO-VACUOLE TARGETING PATHWAY* Masaya Yamaguchi, Nobuo N. Noda, Hitoshi Nakatogawa§, Hiroyuki Kumeta, Yoshinori Ohsumi, and Fuyuhiko Inagaki Department of Structural Biology, Graduate school of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Integ...
JNK signaling functions to induce defense mechanisms that protect organisms against acute oxidative and xenobiotic insults. Using Drosophila as a model system, we investigated the role of autophagy as such a JNK-regulated protective mechanism. We show that oxidative stress can induce autophagy in the intestinal epithelium by a mechanism that requires JNK signaling. Consistently, artificial acti...
In the conserved autophagy pathway, the double-membrane autophagosome (AP) engulfs cellular components to be delivered for degradation in the lysosome. While only sealed AP can productively fuse with the lysosome, the molecular mechanism of AP closure is currently unknown. Rab GTPases, which regulate all intracellular trafficking pathways in eukaryotes, also regulate autophagy. Rabs function in...
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