The present study explored anti-tubercular pyrrole derivatives against cancer targets using different in silico and vitro approaches. Initially, nineteen pyrrolyl benzohydrazide were screened a potent target PLK1 an AutoDock Vina approach. Out of the derivatives, two most C8 [N′-(4-(1H-pyrrol-1-yl) benzoyl)-3-chlorobenzohydrazide] C18 benzoyl)-4-nitrobenzohydrazide], subjected to molecular simu...

The advent of Multi Drug Resistant (MDR) strain of Mycobacterium tuberculosis (TB) necessitated search for new drug targets for the bacterium. It is reported that 3.3% of all new tuberculosis cases had multidrug resistance (MDR-TB) in 2009 and each year, about 0.44 million MDR-TB cases are estimated to emerge and 0.15 million people with MDR-TB die. Keeping such an alarming situation under cons...

We report a case of a 68-year-old female who was a known case of diabetes mellitus and chronic liver disease and presented with complaints of dry cough and other constitutional symptoms since one month. During initial investigations, the patient was found to have peripheral blood eosinophilia. Upon investigating further,the patient was found to have mediastinal lymphadenopathy and fine-needle a...

Tuberculosis (TB) of the breast is a rare form of extra-pulmonary TB, even in countries like India, where TB is still rampant. It commonly affects women in reproductive age group especially during lactation and constitutes 0.64–3.59% of all breast pathologies. It rarely affects children. It presents a diagnostic challenge as it closely mimics carcinoma of the breast and pyogenic inflammatory di...

fractions obtained from partitioning of aerial methanolic extract of euphorbia aellenii with chloroform (e2), ethyl acetate (e3), n-butanol (e4) and water (e5) were investigated in vitro for their phytotoxicity, insecticidal, anti-leishmanial, cytotoxicity, antibacterial and antifungal activities. sample e2 appeared to have significant phytotoxic activity. in the insecticidal screening study on...

ETHNOPHARMACOLOGICAL RELEVANCE The roots of Hibiscus vitifolius Linn. (Malvaceae) is used for the treatment of jaundice in the folklore system of medicine in India. This study is an attempt to evaluate the hepatoprotective activity of the roots of Hibiscus vitifolius against anti-tubercular drug induced hepatotoxicity. MATERIALS AND METHODS Hepatotoxicity was induced in albino rats of either ...

Objectives : Tuberculosis ,though a common condition in our country is still an enigma because of its varied modes of clinical presentation,characteristics and spread. Our objective is to stress the importance of an complete clinical examination and analysis of the symptomatology in arriving at the diagnosis of laryngeal lupus and provide an update on current knowledge and treatment of lupus vu...

MmpL3 is a promising target for novel anti-tubercular agents, with numerous compound series identified as MmpL3 inhibitors. Despite this, there is an incomplete understanding of MmpL3 function. Here we show that Mycobacterium smegmatis MmpL3 mutant strains had an altered cell wall hydrophobicity, disrupted membrane potential and growth defects in liquid media. Compensatory mutations that restor...

Paradoxical response to anti-tubercular drugs remains a diagnostic dilemma. In India where tuberculosis is quite prevalent, paradoxical response to anti-tubercular treatment (ATT) is either misdiagnosed or under-diagnosed. We report two cases of optochiasmatic arachnoiditis due to paradoxical response in children suffering from tuberculous meningitis. Visual acuity was recorded as no light perc...