Sepsis is the main cause of acute kidney injury (AKI), mainly due to systemic immune dysregulation. Kaempferol (KAE) a natural flavonoid compound with multiple biological activities including anti-inflammatory, antioxidant, and antiapoptotic properties. In this study, we constructed sepsis-induced AKI mouse model an LPS-induced glomerular mesangial cell (HK-2) in vitro sepsis model. We found th...

Objectives: Considerable differences are known between proximal and distal colon, these include embryological, anatomical, histological, biochemical, physiological characteristics. Above mentioned distinctions may influence development of variable clinico-morphological entities. Multifunctional antiapoptotic protein survivin participates in regulation cell cycle, apoptotic cascades, stimulates ...

Antiapoptotic myeloid cell leukemia 1 (MCL-1) is an essential modulator of survival during the development and maintenance of a variety of cell lineages. Its turnover, believed to be mediated by the ubiquitin-proteasome system, facilitates apoptosis induction in response to cellular stress. To investigate the contribution of ubiquitinylation in regulating murine MCL-1 turnover, we generated an ...

Lithium and valproate (VPA) have been the most widely prescribed mood stabilizers for the therapy of bipolar disorders (BD) for more than 50 years. However, the precise molecular mechanism of their pharmacological activity is not fully known. Recent studies have suggested that both drugs exert antiapoptotic effects. This review focuses on the influence of lithium and VPA on intracellular apopto...