Drug-induced gingival hyperplasia is the increased growth of epithelium and submucosa which may cause bleeding loss teeth. Certain anticonvulsant, immunosuppressive, antihypertensive drugs are underlying in most cases. Among them, cases due to amlodipine very rare. Here, we discuss topic along with a case overgrowth induced by amlodipine. A 51-year-old female presented overgrowth. She was on be...

The specific nitrogen flame-ionization detector was used for the rapid simultaneous determination of eight anticonvulsant drugs and one drug metabolite in plasma and for three of the drugs in tissues. The system of analysis allows the occasional rapid estimation of barbiturate in plasma. No derivative formation is required and the whole range of drugs can be determined in a single diethyl ether...

Introduction Anticonvulsant drugs have a low therapeutic ratio so that dosage requirements are critical. Their effects are therefore susceptible to the influences of concurrent medication. In common with the anticonvulsants, the non-steroidal anti-inflammatory drugs tend to be highly protein bound and metabolized in the liver. Thus, potential for interaction between these groups of drugs exists...

Introduction: Epilepsy is the second most common nervous disorder after brain strok. In spite of present anticonvulsant drugs, researchers need to search for drugs with better efficacy and less side effects. Medicinal plants with various natural components so that different properties are suitable field for investigation. In this study, anticonvulsant effect of Lavandula vera DC. and Cuscuta ep...

background: lippia citriodora kunth is one of the iranian traditional medicines for the treatment of convulsive disorders. the goal of this study is to investigate the anticonvulsant activity of the plant’s leave ethanolic extract against electro‑ and chemoconvulsant‑induced seizures in mice. methods: the anticonvulsant activity of the extract (200, 400, 800 mg/kg, per os, p.o.) was investigate...

Guanine-based purines have been traditionally studied as modulators of intracellular processes, mainly Gprotein activity. However, more recently, several studies have shown that they exert a variety of extracellular effects not related to G-proteins, including trophic effects on neural cells, modulation of glutamatergic activity, behavioral effects and anticonvulsant activity. In this article, ...

Objective: Crinum jagus is used in traditional African medicine the treatment of epilepsy, pain and inflammations.
 Methods: Anticonvulsant activity was investigated using picrotoxin (PCT) strychnine (STR) tests experimental paradigm.
 Results: leaf methanol extract (200, 400, 800 mg kg−1) potentiated hexobarbitone-induced sleeping time significantly (p<0.05) shortened duration con...

Introduction: Epilepsy is the second most common nervous disorder after brain strok. In spite of present anticonvulsant drugs, researchers need to search for drugs with better efficacy and less side effects. Medicinal plants with various natural components so that different properties are suitable field for investigation. In this study, anticonvulsant effect of Lavandula vera DC. and Cuscuta ep...

The incomplete seizure control with frequent adverse effects of current anticonvulsant drugs and the importance of semicarbazones, quinazolines and 2,5-disubstituted 1,3,4-thiadiazoles as anticonvulsant pharmacophore prompted us to carry out synthesis of three novel series of semicarbazones containing 1,3,4-thiadiazole and quinazoline ring. The chemical structures of these compounds were elucid...

Objective: Agmatine is an endogenous cationic amin and have been reported several neurotherapeutic effects through α2-adrenoceptors, imidazoline binding sites, inhibition of NMDA receptors nitric oxide (NO) synthase. NO was to act as a neuromodulator neurotransmitter in central nervous system has proconvulsant/anticonvulsant activities convulsion models. We aimed compare the anticonvulsant agma...