Posaconazole is a commonly used medication for antifungal prophylaxis in patients with high-risk acute leukemia, such as acute myeloid leukemia. Despite clinical data that show that posaconazole is superior to other antifungal prophylaxis medications, posaconazole is known to have many side effects and drug-drug interactions. We present a patient who developed rhabdomyolysis after being started...

OBJECTIVES The susceptibility of Candida albicans to catechin under varying pH conditions and the synergism of the combination of catechin and antimycotics were evaluated. METHOD Antifungal activity was determined by broth dilution and calculation of cfu. RESULTS The antifungal activity of catechin was pH dependent. The concentration of epigallocatechin gallate (EGCg) causing 90% growth inh...

BACKGROUND The Candida species are the most important factors of fungal infections in humans and animals. It is necessary to prepare antifungal or antimicrobial drugs because of increasing drug resistance. The natural treatment of diseases of bacterial origin using medicinal plants is important. In this study the effect of antimicrobial medicinal herbal essential oils and conventional antifunga...

Sea cucumber is presented as potential marine source of antimicrobial compounds. The purpose of this study is to evaluate antifungal effects of sea cucumber, Holothuria leucospilota, extracts on Aspergillus niger and Candida albicans. Methanol and chloroform extracts of the body wall, gonad and intestine of sea cucumber, H. leucospilota, collected from Persian Gulf, were evaluated for their ant...

Antifungal activity of ethanolic leaf extract of Limonia acidissima was studied against three common dermatophytic fungai like Trichophyton mentagrophytes, Microsporum canis and Epidermophyton floccosum by disc diffusion method and zone of inhibition was determined. Ketoconazle was used as reference control. The ethanolic leaf extract of Limonia acidissima exhibited antifungal activity against ...

Received: April 27, 2017 Revised: July 27, 2017 Accepted: August 10, 2017 Abstract: Background: Biofilm formation by Candida albicans is a significant clinical challenge. Fungal biofilms are resistant to most of the currently available antifungal agents. Amphotericin-B (AmB) is an antifungal agent used for the treatment of systematic fungal infections but it is well known for its toxicities and...

Soil cyanobacteria isolated from the rice paddy fields of 10 different locations across Korea were evaluated by agar plate diffusion test for antifungal activity. Aqueous, petroleum ether, and methanol extracts from one hundred and forty two cyanobacterial strains belonging to the 14 genera were examined for antifungal properties against seven phytopathogenic fungi causing diseases in hot peppe...

BACKGROUND Plagiochin E (PLE) is an antifungal macrocyclic bis(bibenzyl) isolated from liverwort Marchantia polymorpha L. Its antifungal mechanism is unknown. To elucidate the mechanism of action, its effect on mitochondria function in Candida albicans was studied. METHODS We assayed the mitochondrial membrane potential (mtDeltapsi) using rhodamine 123, measured ATP level in mitochondria by H...

cular plants. They are important constituents of human dietary sources, such as fruits and vegetables, and they are also important for the growth, development and defense of plants. There are numerous flavonoids such as apigenin, genistein, narigenin, malvidin chloride and amentoflavone, and flavonoids exhibit various favorable biological and pharmacological effects. Amentoflavone belongs to a ...