Rabbit anti-human ferritin (anti-hFT) polyclonal immunoglobulin G (IgG) and poly(ethylene glycol) (PEG) were sequentially co-immobilized onto polystyrene submicroparticles (sMPs) to construct sMP/anti-hFT/PEG (SAP) immunolatex. Chemical immobilization of anti-hFT was performed at different pH levels to evaluate variations in antigen recognition. Basic pH disfavored conjugation of anti-hFT to sM...

Among advanced melanomas, approximately 60% of the patients present with immunologic ignorance or intrinsic induction tumors need other therapeutic approaches to change an immunologically “cold tumor” “hot by attracting T cells into tumors. We have established immune cell therapy immortalized induced pluripotent stem–cell (iPSC)–derived proliferating myeloid (iPSC–pMCs). The benefits using iPSC...

PURPOSE Our goal is to test whether CS1 could be targeted by chimeric antigen receptor (CAR) T cells to treat multiple myeloma (MM). EXPERIMENTAL DESIGN We generated a retroviral construct of a CS1-specific CAR and engineered primary human T cells expressing the CAR. We then tested the capacity of CS1-CAR T cells to eradicate human MM tumor cells in vitro, ex vivo, and in vivo using orthotopi...

A detailed summary of the published clinical trials of chimeric antigen receptor T cells (CAR-T) and TCR-transduced T cells (TCR-T) was constructed to understand the development trend of adoptive T cell therapy (ACT). In contrast to TCR-T, the number of CAR-T clinical trials has increased dramatically in China in the last three years. The ACT seems to be very prosperous. But, the multidimension...

Rantz and associates (1952, 1956) discovered an unusual antigen which is present in many species of gram-positive and absent in gramnegative bacteria, and referred to it as "nonspecies specific (NSS) antigen." This antigen becomes readily attached to erythrocytes and thus renders the latter specifically agglutinable by antibodies directed against it. Sheep red blood cells modified by Rantz anti...

The acceptance of public participation in science and technology governance in liberal democratic contexts is evident in the institutionalization of a variety of mechanisms for participation in recent decades. Yet questions remain about the extent to which institutions have actually transformed their policy practice to embrace democratic governance of techno-scientific decision making. A critic...

the protective capacity of the crude extracts from larval and nymphal stages of hyalomma anatolicum anatolicum was examined in the new zealand white rabbits. the rabbits were randomly divided into 3 groups of five animals. the rabbits in groups 1 and 2 were immunized with crude extracts of larval and nymphal antigens, respectively and group 3 was served as control. following challenge of each r...

hirchsprung’s disease is a developmental disorder of the enteric nervous system, characterized by abdsence of ganglion cell in the myenterric and submucosal plexuese along a variable portion of the distal intestine.the purpose of this study is the presentation of a new procedure for reduction of the postoperative complications of hirschsprung’s disease (hd) by offering a modified swenson’s tech...

chromium (vi) adsorption behavior and capacity by surface modified nanozeolite a has been investigated. surface modification was performed and the morphology of modified and unmodified nanozeolite was studied using scanning electron microscope (sem) and transmission electron microscope (tem). adsorption isotherms were studied under different conditions (ph, adsorbent dose, adsorbate concentrati...