A new class of agents has been made available for the treatment of hypertension. These calcium antagonists have rapid bioavailability and dramatic antihypertensive effects through reduction of total peripheral resistance and the vascular resistance of the major target organs of the body. These changes are usually associated with unchanged cardiac output, preserved organ blood flows, maintained ...

The present investigation was undertaken to evaluate the effect of antihypertensive drugs on aortic atherogenesis in hypercholesterolemic rabbits. In enalapril and nifedipine treated rabbits aortic atherosclerotic plaque involvement was significantly decreased (p<0. Oland p<O. 05, respectively) as compared to the control group. However, in hydrochlorothiazide treated rabbits aortic atheroge...

Mukesh C. Sharma Dept. of Pharmaceutical Sciences, Dr.Hari Singh Gour University Sagar (M.P) 470003 India Department of Chemistry Yadhunath Mahavidyalya Bhind (M.P) 477001 India Email: [email protected] Abstract In this study we have synthesized some Benzimidazole derivatives (2-{6Chloro-5-nitro-1-[2-(1H-tetrazol-5-yl) biphenyl-4-ylmethyl] 1Hbenzoimidazol-2-yl}-phenyl)-(Substituted-benzyl...

Novel antihypertensive peptides released by Kluyveromyces marxianus from bovine lactoferrin (LF) have been identified. K. marxianus LF permeate was fractionated by semipreparative high performance liquid chromatography and 35 peptides contained in the angiotensin I-converting enzyme (ACE)-inhibitory fractions were identified by using an ion trap mass spectrometer. On the basis of peptide abunda...

An in vivo study has been carried out to evaluate the synergism of diltiazem and nifedipine on the antihypertensive activity and the effect of ketotifen fumerate and potassium nitrate on this phenomenon of synergism in rabbit. It has been found that the lowering of blood pressure by concurrent administration of diltiazem and nifedipine was not equal to the sum of lowering of blood pressure by i...

The aim of this study was to assess the contribution of physical activity levels to blood pressure (BP) variability, and to assess the effect age, gender, body mass index, and use of antihypertensive medications on this relationship. We simultaneously monitored 24-h ambulatory BP by automated recorder and activity by actigraphy in 431 patients. Mean activity scores for the 5, 10, 15, and 20 min...