Case-control studies have shown that regular use of nonsteroidal antiinflammatory drugs (NSAIDs) decreases bladder cancer risk, but few cohort studies have evaluated this association. The authors investigated NSAID use and bladder cancer in 3 large prospective studies (NIH-AARP Diet and Health Study; Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial; and U.S. Radiologic Technologist...

N onsteroidal antiinflammatory drugs (NSAIDs) and prostanoids continue to be fascinating research targets. Humans have been using NSAIDs in one form or another, from folk remedies through to the products of modern pharmaceutical research, for thousands of years. However, we still have not characterized all of the systems through which these drugs produce their beneficial and harmful effects (1,...

Nonsteroidal antiinflammatory drugs (NSAIDs) are drugs commonly prescribed in dental practice for the management of pain and swelling. Of these substances, paracetamol and ibuprofen are the most widely used. Their mechanism of action is based on the inhibition of cyclooxygenase, and therefore of prostaglandin synthesis. All of these drugs present a similar mechanism of action, as a result of wh...

Conium maculatum Linn. (Umbelliferae) has been traditionally used in the treatment of spasmodic disorders, and to relieve nervous excitation, rheumatic pains in the old and feeble, pain in stomach, pain of gastric ulcer, nervousness and restlessness. Alkaloids have long been considered as bioactive group of constituents present in C. maculatum. Despite a long tradition of use, C. maculatum has ...

36.Antiinflammatory and Antirheumatic Drugs 423 Karen A. Woodfork and Knox Van Dyke 37.Drugs Used in Gout 441 Knox Van Dyke 38.Histamine and Histamine Antagonists 449 Knox Van Dyke and Karen A. Woodfork 39.Drugs Used in Asthma 458 Theodore J. Torphy and Douglas W. P. Hay 40.Drugs Used in Gastrointestinal Disorders 470 Lisa M. Gangarosa and Donald G. Seibert 41.Drugs Used in Dermatological Disor...

Interactions between anti-inflammatory drugs and anti-diabetic drugs particularly sulphonylureas are known. Nonsteroidal anti-inflammatory drugs (NSAIDs) like aspirin, phenylbutazone and oxyphenbutazone are known to potentiate (I, 4, 5) and indomethacin and ibuprofen are known to antagonise the hypoglycaemic effect of oral sulphonylurea drugs (2). On the other hand Wellinger et al. (12) reporte...