Submit Manuscript | http://medcraveonline.com treating these and other bacterial infections currently exist; there is still an essential need for new and improved approaches for bacterial destruction. Nanomedicine is one approach to overcome challenges of conventional drug delivery systems based on the development and fabrication of nanostructures. Various types of nanoparticulate systems have ...

Despite many recent advances in antimicrobial therapy, resistance among Gram-positive pathogens continues to pose a serious and growing clinical problem. Indeed, over the past 15 years, there has been a steady erosion in the activity of many antimicrobials against certain Grampositive pathogens. The clinical impact of this escalating resistance is underscored by the findings that Staphylococcus...

In late 2001, a group of South Australian metropolitan public and private hospitals commenced voluntary contribution of data on in-hospital utilisation of antimicrobials to the Communicable Disease Control Branch of the Department of Human Services. Where possible, hospitals contributed data on all antimicrobials dispensed for use within the institution each month. These data were stratified in...

Neisseria gonorrhoeae is evolving into a superbug with resistance to previously and currently recommended antimicrobials for treatment of gonorrhea, which is a major public health concern globally. Given the global nature of gonorrhea, the high rate of usage of antimicrobials, suboptimal control and monitoring of antimicrobial resistance (AMR) and treatment failures, slow update of treatment gu...

Some drug management systems have been established in Japanese hospitals to reduce medical costs and regulate drug usage. Among the many available prescription drugs, antimicrobials should be given special attention because their inappropriate use often leads to sudden outbreaks of resistant bacteria. As drug specialists, pharmacists should monitor the use of all drugs, particularly antimicrobi...

The susceptibilities to three antimicrobials of 195 Helicobacter pylori strains isolated from Mexican patients is reported; 80% of the strains were resistant to metronidazole, 24% were resistant to clarithromycin, and 18% presented a transient resistance to amoxicillin. Resistance to two or more antimicrobials increased significantly from 1995 to 1997.

In vitro antistaphylococcal activities of panduratin A, a natural chalcone compound isolated from Kaempferia pandurata Roxb, were compared to those of commonly used antimicrobials against clinical staphylococcal isolates. Panduratin A had a MIC at which 90% of bacteria were inhibited of 1 microg/ml for clinical staphylococcal isolates and generally was more potent than commonly used antimicrobi...

The aim of this study was to investigate the prescribing of antimicrobials in private primary health care in South Africa. A retrospective drug utilisation study was conducted on data obtained from the database of nine private primary health care clinics for the year 2001. Antimicrobials were classified pharmacologically and their usage analysed according to number of patients and consultations...

Staphylococcus aureus and Pseudomonas aeruginosa are part of the human microbiota and are also important bacterial pathogens, for which therapeutic options are lacking nowadays. The combined administration of corticosteroids and antimicrobials is commonly used in the treatment of infectious diseases to control inflammatory processes and to minimize potential toxicity of antimicrobials, avoiding...

Efficient use of natural antimicrobials in food is predicated on the proper implementation of hurdle technology. These substances are meant to increase the robustness of existing food safety or quality assurance programs, not to correct or mask poor practices. The objective of this paper is to outline the important aspects of application of natural antimicrobials to foods, including selection o...