Antimonial agents are a mainstay for the treatment of leishmaniasis, a group of protozoal diseases that includes visceral leishmaniasis, or Kala Azar. Chemotherapy with trivalent potassium antimony tartrate (PAT) and, more importantly, pentavalent antimony-carbohydrate complexes, such as sodium stibogluconate (SSG), has been reported to prolong the QT interval and produce life-threatening arrhy...

Background: Leishmania infection is a serious worldwide health concern that caused by various types of parasite genus. Current therapies for this disease, including pentavalent antimonial complexes, are not safe and do have enough efficacy. The Artemisia aucheri spring leaf extract has been reported to antimicrobial effects on variety pathogens. Objective: This study aimed find how A. affects t...

visceral leishmaniasis (vl) is usually treated with pentavalent antimonial drugs given alone or in combination with other drugs. the efficacy of these treatments is diminishing, however, and development of alternative treatments has been recommended.we studied 13 patients with leishmaniasis who were unresponsive to meglumine antimonate, at a dose of 20 mg/kg body weight/per day given for 30 day...

we describe a case of visceral leishmaniasis (vl) due to leishmania tropica in a 50-year-old iranian man lived in a vl-endemic area in southwest of iran. the patient presented with a 3-month history of fever and splenomegaly. clinical signs and serological findings were suggestive of vl. spleen biopsy was taken from the patient and intracellular forms of leishmania amastigotes was seen in giems...