Peripheral T-cell lymphomas (PTCLs) are rare neoplasms that recently have been the subject of much research into their complex pathophysiology. PTCLs a heterogeneous group tumors consisting nodal and extranodal leukemic cutaneous neoplasms. associated with biology arduous pathology which is currently being studied. According to this research, pathophysiology can be divided intrinsic extrinsic m...

76. Connor TH, Anderson RW, Sessink PJ et al. Effective-ness of a closed-system device in containing surface contamination with cyclophosphamide and ifosfamidein an i.v. admixture area. Am J Health-Syst Pharm. 2002; 59:68–72.77. Vandenbroucke J, Robays H. How to protect environ-ment and employees against cytotoxic agents: the UZGent experience. J Oncol Pharm Pract. 2001;...

Over the past forty years, anthracyclines and ellipticines have attracted attention as promising cytostatics. In this review, we focus on their mechanisms of cytoxicity, DNA-damaging effects and adverse side-effects. We also summarize ways to enhance the therapeutic effects of these drugs together with a decrease in their adverse effects. Current drug design strategies are focused on drug bioav...

OBJECTIVES Given the increasing use of oral antineoplastic agents in cancer management, patient adherence is critical to successful treatment outcomes. This article reviews the scope of the problem and issues of adherence to oral antineoplastic agents. DATA SOURCES Research-based and other articles, newsletters, and conference presentations. CONCLUSION Suboptimal adherence to oral antineopl...

Does the administration of antioxidants during cancer chemotherapy affect antineoplastic efficacy or the development of side effects? Although the majority of preclinical studies involving the use of in vitro systems and animal models support the contention that certain antioxidants are of benefit, few clinical studies have been done (1,2). Factors to consider in the design of studies to answer...

INTRODUCTION Studies on bioavailability are part of the clinical development of drugs for oral use in order to identify potential drug-food interactions. For oral antitumor drugs, their clinical importance is currently recognized although regrettably the information available presents variability concerning the scientific evidence. OBJECTIVES To review the available scientific evidence about ...

Ellipticine is a potent antineoplastic agent exhibiting the multimodal mechanism of its action. This article reviews the mechanisms of predominant pharmacological and cytotoxic effects of ellipticine and shows the results of our laboratories indicating a novel mechanism of its action. The prevalent mechanisms of ellipticine antitumor, mutagenic and cytotoxic activities were suggested to be inte...

Doxorubicin is a commonly used antineoplastic agent in the treatment of many types of cancer. Little is known about the interactions of doxorubicin with cardiac biomolecules. Serious cardiotoxicity including dilated cardiomyopathy often resulting in a fatal congestive heart failure may occur as a consequence of chemotherapy with doxorubicin. The purpose of this study was to determine the effect...