Twenty to thirty percent of patients with atopic dermatitis (AD) are positive for antinuclear antibodies (ANAs). In this study we investigated the prevalence of ANA in 100 patients with AD and examined the difference between ANA-positive (ANA+) and ANA-negative (ANA(-)) patients with AD. ANAs were identified with indirect immunofluorescence on Hep-2 cells. Nineteen patients (19%) with AD were f...

A 17-year-old male with type 1 diabetes mellitus (T1DM) presented to clinic with elevated transaminases and a positive antinuclear antibody (ANA) screen. Due to concern for autoimmune hepatitis, a liver biopsy was performed which revealed Mauriac syndrome. This case report is the second known description of a child with Mauriac syndrome presenting with positive autoimmune markers.

Systemic lupus erythematosus is a multisystem inflammatory disease characterized by antinuclear antibody production. The diagnosis of this disease is established on the basis of a constellation of clinical and serologic features. Therapy is directed to specific disease manifestations and involves an array of anti-inflammatory and immunosuppressive agents that are administered judiciously to lim...

Articular manifestations are a frequent but often underdiagnosed manifestation in patients infected with the human immunodeficiency virus (HIV). We present a 7-year-old HIV-infected malnourished girl who presented with recurrent joint pain and effusion in the left knee joint. Her antistreptolysin O, dsDNA, antinuclear antibody and rheumatoid arthritis factor were negative. She responded to anti...

The horseradish peroxidase bridge method described by Mason, Phifer, Spicer, Swallow, and Dreskin (1969) has been found to be as sensitive and specific as fluorescence methods for detecting antinuclear factor and gastric parietal cell antibody, and to a lesser extent, antibodies to smooth muscle and mitochondria. However, the method has at least four practical advantages over fluorescence techn...

Submit Manuscript | http://medcraveonline.com Abbreviations: APDE: Acquired Platelet Dysfunction with Eosinophilia; AEC: Absolute Eosinophil Count; ADP: Adenosine Diphosphate; RiCof: Platelet Ristocetin Cofactor; APTT: Activated Partial Thromboplastin Time; PT: Prothrombin Time; SFLC: Serum Free Light Chains; IgA: Immunoglobulin A; aVWD: Acquired Von Willebrand Disease; FVIII: Factor VIII; FIX:...