The aim of the study was to develop a new complex treatment ulcerative colitis using integrative medicine methods. conducted on 16 patients with total (8 patients) and left-sided lesions patients). progress disease traced basis complaints, levels fecal calprotectin lactoferrin, ESR endoscopic picture colon mucosa. Depending severity individual characteristics disease, lasted 2-8 months. carried...

Atovaquone is a unique naphthoquinone with broad-spectrum antiprotozoal activity. It is effective for the treatment and prevention of Pneumocystis carinii pneumonia (PCP), it is effective in combination with proguanil for the treatment and prevention of malaria, and it is effective in combination with azithromycin for the treatment of babesiosis. There is also limited experience with other prot...

Tethering known drugs to a metalorganic moiety is an efficient approach for modulating the anticancer, antibacterial, and antiparasitic activity of organometallic complexes. This study focused on synthesis evaluation new dinuclear ruthenium(II)–arene compounds linked several antimicrobial such as dapsone, sulfamethoxazole, sulfadiazine, sulfadoxine, triclosan, metronidazole, ciprofloxacin, well...

Based on crystallographic data of the complexes 2-alkyl(amino)ethyl-1,1-bisphosphonates-Trypanosoma cruzi farnesyl diphosphate synthase, some linear 1,1-bisphosphonic acids and other closely related derivatives were designed, synthesized and biologically evaluated against T. cruzi, the responsible agent of Chagas disease and against Toxoplasma gondii, the etiologic agent of toxoplasmosis and al...

High-throughput screening of 100,000 lead-like compounds led to the identification of nine novel chemical classes of trypanothione reductase (TR) inhibitors worthy of further investigation. Hits from five of these chemical classes have been developed further through different combinations of preliminary structure-activity relationship rate probing and assessment of antiparasitic activity, cytot...

Immunoglobulins from individuals with immunity to malaria have a strong antiparasitic effect when transferred to Plasmodium falciparum malaria infected patients. One prominent target of antiparasitic antibodies is the merozoite surface antigen 3 (MSP-3). We have investigated the antibody response against MSP-3 residues 194 to 257 (MSP-3(194-257)) on the molecular level. mRNA from peripheral blo...

Abstract Neospora caninum is an apicomplexan parasite that causes abortion in cattle, resulting significant economic losses. There no commercial treatment for neosporosis, and drug repositioning a fast strategy to test possible candidates against N. caninum. In this article, we describe the effects of atovaquone, chloroquine, quinine, primaquine tetracycline on proliferation. The IC50 concentra...

Nitroimidazoles are pharmacophoric groups responsible for important antiparasitic activity against several infectious diseases. 2-Nitroimidazoles found in some drugs and one of the main moieties biological activities exhibited. As an example, we can mention drug benznidazole, only available Brazil treatment Chagas disease. This work describes efficient methodology synthesis 2-nitro-1-vinyl-1H-i...

ABSTRACT The objective of the study was to evaluate antiparasitic resistance against horse nematodes in South Rio Grande do Sul, Brazil. results concerning tests anthelmintic efficacy on horses, stored database Parasitic Diseases Study Group (GEEP) - Veterinary Faculty, at Federal University Pelotas (UFPel), were carried out laboratory from 2018 2019. Stool samples received farms with breeding ...

The presence of Charcot-Leyden Crystals in liver biopsy is rare. A report case a 14-year-old boy who presented with persistent fever and respiratory symptoms. Chest X-ray CT thorax showed miliary infiltrates. Mantoux test was positive sputum for acid-fast bacilli (AFB) negative. patient started antitubercular therapy (ATT). There no response the still had fever. Further evaluation an ultrasound...