نتایج جستجو برای: antipruritic
تعداد نتایج: 204 فیلتر نتایج به سال:
Background: This research deals with the indigenous medicinal plants used by rural population of Artvin-Borçka (Zorlu village), for treatment gynecological disorders. For this purpose, ethnomedicinal survey Zorlu village in Turkey was carried out during 2008-2009. Methods: In present study, a two-part made. The first part determined folk medicine Second were uses plants. Results: Local inhabita...
Abstract In recent decades, the therapeutic potential of cannabinoids and analogous compounds has been intensively investigated. The endocannabinoid system already identified in skin and, although much remains to be discovered about its contribution importance for maintenance homeostasis, it increasingly associated as promising dermatological disorders’ management. Cannabidiol (CBD), main non-i...
Chronic itch in atopic dermatitis is a significant clinical problem with unmet needs. Pain also common symptom of dermatitis. Crisaborole, PDE-4 inhibitor, approved for the treatment mild to moderate The inhibitor appears reduce by activating cAMP-PKA pathway. However, mechanism underlying this antipruritic effect has not fully understood. mouse model was developed repeatedly applying MC903. Cr...
Primary sensory neurons in the dorsal root ganglia and trigeminal ganglia are responsible for sensing mechanical and thermal stimuli, as well as detecting tissue damage. These neurons express ion channels that respond to thermal, mechanical, or chemical cues, conduct action potentials, and mediate transmitter release. These neurons also express a large number of G-protein coupled receptors, whi...
UNLABELLED Central serotonin (5-hydroxytryptophan, 5-HT) modulates somatosensory transduction, but how it achieves sensory modality-specific modulation remains unclear. Here we report that enhancing serotonergic tone via administration of 5-HT potentiates itch sensation, whereas mice lacking 5-HT or serotonergic neurons in the brainstem exhibit markedly reduced scratching behavior. Through phar...
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