Lurie et al. ' have found that administration of thyroid hormones can increase the level of native resistance to tuberculosis in rabbits, and that thyroidectomy and antithyroid drugs have the opposite effect. On the other hand, the harmful effects of iodides on the clinical manifestations of human leprosy are well known. 0 'Byrne2 and Roj as' have reported favourable responses in the treatment ...

The management of hyperthyroidism in the pregnant woman has been the topic of several recent reviews (1–6) and case series (7–8). These papers have discussed maternal-fetal thyroid relationships, the epidemiology of maternal hyperthyroidism, causes of gestational thyrotoxicosis, the clinical and laboratory diagnosis of hyperthyroidism in pregnancy, therapy with ATDs, surgery, b adrenergic block...

Peripheral immunoglobulin (Ig) G(3)-secreting cells and serum concentrations of interleukin (IL)-10, a class-switching factor to IgG(3)-secreting cells, increase in patients with intractable Graves' disease (GD). However, they are not practical for laboratory tests. To find more stable and easily detectable markers of disease intractability or disease severity in patients with GD or Hashimoto's...

Short title: Antithyroid drugs and birth defects

We have previously shown that a long noncoding RNA transcript Heg is negatively correlated with TSH receptor autoantibodies (TRAb) in patients with untreated Graves' disease and with CD14 mRNA in treated patients and controls. Thus patients with high concentrations of Heg RNA have low levels of TRAb or CD14 mRNA, respectively. Here we show that an additional factor, gene expression of Cdk1 in m...

Following O'Byrne's report ( If)) of the efficacy of antithyroid drugs in leprosy, an examination of the mechanism of action of methimazole in lepromatous leprosy was undertaken. In a preliminary report of this study (n), a lack of correspondence was noted be tween the clinical appearance of the patients and the histopathologic appearance of serial skin biopsies obtained during methimazole ther...

The present study was undertaken to evaluate whether the normalization of the serum TSH level in a supersensitive assay during the initial treatment with antithyroid drugs (ATD) is a useful indicator for the reduction of the initial dose of ATD in 50 patients with hyperthyroidism due to Graves' disease. The initial dose of ATD was continued until the achievement of the euthyroid state, and was ...

The clinical, biochemical and immunological features of 180 patients with hyperthyroid Graves' disease managed at the Universiti Kebangsaan Malaysia (UKM) Endocrine Clinic from 1983 to 1987 were examined. The prevalence of the disease is highest in Chinese and lowest in Indians. The female: male ratio is 2.8:1. Hypokalaemic periodic paralysis and hypercalcaemia were present in 5.0% and 1.7% of ...