TheAmericanPsychiatricAssociation (APA)haspublished the fifth edition of itsDiagnostic and Statistical Manual of Mental Disorders (DSM-5; APA, 2013a), which is considered to be a definitive reference for the diagnosis of psychiatric disorders. TheDSM-5revisionprocess involvedtheappointmentofWorkgroups (andsubworkgroups) foreachsection.Theparaphilias subworkgroup (PSWG) reviewedand recommendedch...

Delay in the Diagnosis of Conn’s Syndrome: A Single-Center Experience Over 30 Years To the Editor: The study reported by Rossi et al1 addressed predictors of outcome in aldosterone-producing adenoma (APA) patients postadrenalectomy. The time-dependent process of adverse vascular remodeling, determined by an increased media/lumen ratio of resistance arteries, was hypothesized to predict a poorer...

Aminopeptidase A (APA) cleaves the N-terminal aspartyl acid residue of angiotensin II (Ang II) to produce angiotensin III (Ang III). It has been reported that the APA knockout mouse exhibits elevated blood pressure. Therefore, the APA gene is thought to be a susceptibility gene for essential hypertension (EH). However, extensive studies have yet to define the relationship between the APA gene a...

OBJECTIVE To use a new immunologic assay to evaluate antipolymer antibody (APA) levels among women with silicone breast implants (SBIs). METHODS Women (n = 186) were identified through Danish population-based registers and categorized into six groups defined by prior breast surgery (silicone breast implantation/breast reduction/no breast surgery) and by the presence or absence of a prior hosp...

mRNA alternative polyadenylation (APA) plays a critical role in post-transcriptional gene control and is highly regulated during development and disease. However, the regulatory mechanisms and functional consequences of APA remain poorly understood. Here, we show that an mRNA 3' processing factor, Fip1, is essential for embryonic stem cell (ESC) self-renewal and somatic cell reprogramming. Fip1...

The clinical significance of anti-pituitary antibodies (APA) was examined by enzyme-linked immunosorbent assay (ELISA) in individuals with non-insulin dependent diabetes mellitus (NIDDM). Serum samples were obtained from 150 NIDDM patients and 45 normal subjects. Urinary C-peptide (UCPR) was also measured for the NIDDM patients. APA-positive serum was incubated with porcine pancreas, liver, kid...

We propose two new affine projection algorithms (APA) with variable regularization parameter. The proposed algorithms dynamically update the regularization parameter that is fixed in the conventional regularized APA (R-APA) using a gradient descent based approach. By introducing the normalized gradient, the proposed algorithms give birth to an efficient and a robust update scheme for the regula...

background orientation of the stylohyoid complex (shc) may be important for evaluation of the patient with orofacial pain or dysphagia. objectives our purpose was to assess the length and angulations of shc using cone beam computed tomography (cbct). patients and methods in this study, 3d images provided by cbct of 69 patients (36 females, 33 males, age range 15-77 years) were retrospectively e...

BACKGROUND Primary aldosteronism (PA) is a most common cause of secondary hypertension. In PA, left ventricular hypertrophy (LVH) is more progressive than in any other cause of hypertension. Aldosterone-producing adenoma (APA) and idiopathic hyperaldosteronism (IHA) are major subtypes of PA. However there is little information concerned with differences of cardiac structures between these two s...

Antiphospholipid antibodies (APA) are associated with thrombosis, thrombocytopenia and fetal loss but they occur in a variety of diseases. Despite many efforts, a correlation between the specificity of particular subgroups of APA and particular clinical situations remains to be established. The antigens at the origin of APA remain to be identified. We discuss here the possible links between cel...