High levels of HDL-cholesterol (HDL-C) protect against coronary heart disease susceptibility, but the metabolic mechanisms underlying elevated HDL-C levels are poorly understood. We now report the turnover of isologous radioiodinated HDL apolipoproteins, apo A-I and apo A-II, in 15 female subjects on a metabolic diet with HDL-C levels ranging from 51 to 122 mg/dl. The metabolic parameters, frac...

Low HDL-cholesterol (HDL-C) levels may elevate atherosclerosis risk, and often associate with hypertriglyceridemia (HTG); however, the metabolic causes of low HDL-C levels with or without HTG are poorly understood. We studied the turnover of radioiodinated HDL apolipoproteins, apo A-I and apo A-II, in 15 human subjects with low HDL-C, six with normal plasma TG levels (group 1) and nine with hig...

The influence of different fibrates on apolipoprotein metabolism was investigated. Administration of fenofibrate provoked a dose-dependent decrease in plasma cholesterol concentration that was already evident after 1 day. Intestinal apolipoprotein (apo) A-I and apo A-IV mRNA levels remained fairly constant. In contrast, liver apo A-I, apo A-II, and apo A-IV mRNA levels decreased in a dose-depen...

Plasma HDL can be classified according to their apolipoprotein content into at least two types of lipoprotein particles: lipoproteins containing both apo A-I and apo A-II (LP A-I/A-II) and lipoproteins with apo A-I but without apo A-II (LP A-I). LP A-I and LP A-I/A-II were isolated by immuno-affinity chromatography. LP A-I has a higher cholesterol content and less protein compared to LP A-I/A-I...

objective(s): apolipoprotein e genotype (apoe) polymorphism affects lipid levels and coronary artery disease (cad) risk. the aim of this study was to study the association of the apolipoprotein e genotypes with coronary artery disease in the iranian population.   materials and methods: the apolipoprotein e genotype in dna samples extracted from 66 cad+ patients and 61 control subjects by restri...

Background: The association between coronary artery disease and androgenic alopecia has been demonstrated, but few studies have focused on the mechanism of this association. The aim of this study was to evaluate the lipid profile in male pattern alopecia.Methods: In this case control study, 45 male patients with androgenic alopecia who were aged from 20 to 50 years and 45 men with a norma...