Apolipoproteins are important constituents of lipoprotein particles and play a central role in the transport and metabolism of lipids (Goldstein et al., 1983). Different lipoproteins and apo have been identified. Recent epidemiological studies have shown the importance of the apolipoprotein B, and its direct correlation with the incidence of coronary heart disease (Sattar et al., 2004; Olofsson...

Two major species of human apolipoprotein (apo) B have been identified, apo B-48 and apo B-100, which are the predominant forms in chylomicrons and very low density lipoproteins (VLDL), respectively. Due to defective hepatic clearance, apo B-48 containing lipoproteins accumulate in the plasma of subjects with type III hyperlipoproteinemia. In the present study, we have used immunoaffinity chrom...

abstract   background: recently, small dense low density lipoprotein (sdldl) has been highlighted as a new risk factor for the coronary artery disease (cad).small dense ldls are believed to be atherogenic since these particles are taken up more easily by arterial wall. they are readily oxidized and have reduced affinity for low density lipoprotein (ldl) receptor and increased affinity for arter...

We have reported previously on two truncations of apolipoprotein B (apo B-40 and apo B-89) in a kindred with hypobetalipoproteinemia. Premature stop codons were found to be responsible for both apo B-40 and apo B-89, but the physiologic mechanisms accounting for the reduced plasma concentrations of these proteins have not been determined in vivo. This study investigates the metabolism of apo B-...