The electrophoresis pattern of apoptotic cells detected by the comet assay has a characteristic small head and spread tail. This image has been referred to as an apoptotic comet, but it has not been previously proven to be apoptotic cells by any direct method. In order to identify this image obtained by the comet assay as corresponding to an apoptotic cell, the frequency of appearance of apopto...

Biodegradable polymeric nanoparticles (NPs) have been intensively studied as a possible way to enhance anti-tumor efficacy while reducing side effects. ICD-85, derived from the venom of two separate species of venomous animals, has been shown to exhibit anti-cancer activity. In this report polymer based sodium alginate nanoparticles of ICD-85 was used to enhance its therapeutic effects and redu...

Background MicroRNAs are small and non-coding RNA molecules with approximately 22 nt in length that cause inhibition of translation or degradation of mRNA. MiR-155 is a kind of molecule with different functions, such as its role in proliferation, apoptosis, inflammation, differentiation, and immunity. One of its best known functions is apoptosis that affects on caspase-3 activity. The main aim...

Background and objectives: Plants have been used to treat diseases like cancer for many years and today the trend towards their use is increasing. One of the most effective mechanisms of plants against cancer is inducing apoptosis. Apoptosis is a programmed cell death which acts opposite to cell division. It starts in response to some stimuli. Despite the effectiveness of apopt...

Aims: The biosynthesis of nanoparticles is widely considered today. The aim of this investigation was the biosynthesis and coating of Ag.NPs with Zataria multiflora (Zm-Ag.NPs) leaf extract and assess its apoptosis promoting effects. Methods: The Zm-Ag.NPs was characterized by UV-visible and FTIR spectroscopy, TEM, EDS, DLS and measurement of zeta-potential. Apoptosis induction effects of Zm-A...

Glioma is the most common type of brain cancer. Chemotherapy combination with surgery and radiotherapy a standard treatment for patients. Although there are many advances in glioma therapy, prognosis patients has not significantly been improved over past decades. Hence, still an urgent need to develop new therapy treat glioma. Cell viability was assessed by CellTiter Blue assay; flow cytometry ...

Myocardial infarction is a serious representation of cardiovescular disease, MicroRNAs play role in modifying I/R injury and myocardial infarct remodeling. The present study therefore examined the potential miR-187 cardiac its underlying mechanisms. was inhibited or overexpressed cardiomyocytes H/R models by pretreatment with mimic inhibitor to confirm function H/R. DYRK2 inhibitor. A myocardiu...

INTRODUCTION A growing interest in apoptosis, programmed cell death, in the last years is observed and leads to better understanding of molecular mechanisms during cell-cell signaling, cell-environment interaction and screening of drugs. This in turn results in emerging of new assays and development of more accurate kits for fast and early detection of apoptosis. However, their sensitivity and ...

Currently, malignant diseases are one of the leading causes mortality worldwide. Antarctic yeasts represent a poorly explored source novel bioactive compounds with antineoplastic activity and expected favourable toxicological profile. The aim work was evaluation antiproliferative proapoptotic potential extracts obtained from psychrophilic strain Sporobolomyces roseus AL103. Data MTT dye reducti...

objective: leishmaniasis is one of the significant causes of morbidity and mortality in several countries. it is an important problem in endemic areas such as iran. the goal in treatment of leishmaniasis is to reduce the disease period and leave no evidence of any remaining scars or lesions. a derivative of artemisinin is artemether. scientists believe that the strong action of artemether again...