OBJECTIVE In order to study the role of the p53 tumour suppressor gene in the proliferation of rheumatoid arthritis (RA) synovium, we analysed the mutation of p53 in the synovial fibroblast-like type B synoviocyte from RA patients. METHODS Synovial fibroblast-like type B synoviocytes were prepared from the synovial tissues from nine Japanese patients with RA. The p53 cDNA region from exons 4-...

Srinivasan, Suseela, Jennifer Strange, Feyisola Awonusonu, and Margaret C. Bruce. Insulin-like growth factor I receptor is downregulated after alveolarization in an apoptotic fibroblast subset. Am J Physiol Lung Cell Mol Physiol 282: L457–L467, 2002; 10.1152/ajplung.00050. 2001.—After alveolar formation, 20% of interstitial lung fibroblasts undergo apoptosis, a process that is of critical impor...

Multimodal therapy has been recognized as a powerful platform for the precise treatment of cancer. However, reported multimodal therapeutic systems often involve sophisticated components and tedious fabrication procedures. As such, developing nature-inspired easily-obtainable theranostic agents cancer remains challenging. In this work, we propose nanothylakoids agent both in vitro vivo. Nanothy...

BACKGROUND Lubricin/proteoglycan 4 (PRG4) is a mucinous glycoprotein secreted by synovial fibroblasts and superficial zone chondrocytes. Recently, we showed that recombinant human PRG4 (rhPRG4) is a putative ligand for CD44 receptor. rhPRG4-CD44 interaction inhibits cytokine-induced rheumatoid arthritis synoviocyte proliferation. The objective of this study is to decipher the autocrine function...

PURPOSE To evaluate the efficacy and safety of hypericin-enhanced argon laser photocoagulation (H-ALP) in the treatment of subfoveal choroidal neovascular membrane (CNM) secondary to age-related macular degeneration (ARMD). METHODS After preliminary studies for definition of parameters, argon-green laser was administered 4 hours after single dose of oral 1800 mg hypericin (Saint-John's wort t...