Bim is a pro-apoptotic member of the Bcl-2 protein family. Overexpression of Bim proved to be highly cytotoxic for diverse cells. The AD293 cell line is derived directly from the HEK293 cell line but has been transfected with a gene that can improve cell adherence. We found that there was almost no apoptosis seen in Bim L-transfected AD293 cells, but more than half of Bim L-transfected HEK293 c...

objective(s): the oct4b1, as one of oct4 variants, is expressed in cancer cell lines and tissues more than other variants and plays an important role in apoptosis and stress (heat shock protein) pathways. the present study was designed to determine the effects of oct4b1 silencing on expressional profile of hsp40 gene family expression in three different human tumor cell lines. materials and met...

Three closely related clones of leukemic lymphoid CEM cells were compared for their gene expression responses to the glucocorticoid dexamethasone (Dex). All three contained receptors for Dex, but only two responded by undergoing apoptosis. After a time of exposure to Dex that ended late in the interval preceding onset of apoptosis, gene microarray analyses were carried out. The results indicate...

Abstract Background Endometrial cancer is an invasive gynecological prevalent in the world. The pathogenesis of endometrial related to multiple levels regulation, referring oestrogen, tumor-suppressor gene (e.g. PTEN ) or microRNAs miR-23a and miR-29b). Metapristone a hormone-related drug, which widely used clinical treatment cancer. However, underlying regulatory mechanism metapristone on stil...

Effects of Resveratrol Supplementation and Exercise on Apoptosis, Lipid Profile, Expression Farnesoid X Receptor, Liver Receptor Sirtuin 1 Genes in the Type Diabetic Rats

When megalopa molting to the first juvenile crab stage, crabs undergo carcinization morphogenesis. To study key physiological and morphological processes in carcinization, we performed a comparative transcriptomic analysis between cephalothoraxes pleons of stage Chinese mitten crab. The results reveal that major changes pleon were related energy metabolism (oxidative phosphorylation AMPK pathwa...