UNLABELLED Complex periorbital subunit reconstruction is challenging because the goals of effective reconstruction vary from one individual to another. The purpose of this article is to explore the indications and anatomic feasibility of periorbital transplantation by reviewing our institutional repository of facial injury. METHODS Institutional review board approval was obtained at the R Ada...

BACKGROUND Angiogenesis is a contributing factor in some retinal diseases, hence the role of vascular endothelial growth factor (VEGF) as a common pathway in proliferative retinopathies. Bevacizumab has been found to be effective in the treatment of these diseases. The aim of this study was to review all cases of intravitreal bevacizumab given in the retinal unit of the University College Hospi...

The field of peripheral nerve stimulation (PNS) is now experiencing a phase of rapid growth in number of patients, number of implanters, number of indications, and procedure types. This, however, appears to be only a beginning of major developments that could revolutionize the field of PNS. It is expected that the progress in PNS will continue simultaneously in several directions as new indicat...

The application of established drug compounds to new therapeutic indications, known as drug repositioning, offers several advantages over traditional drug development, including reduced development costs and shorter paths to approval. Recent approaches to drug repositioning use high-throughput experimental approaches to assess a compound's potential therapeutic qualities. Here, we present a sys...

The rate of new drug approvals in the US has remained essentially constant since 1950, while the costs of drug development have soared. Many commentators question the sustainability of the current model of drug development, in which large pharmaceutical companies incur markedly escalating costs to deliver the same number of products to market. This Issue Brief summarizes the problem, describes ...

Title of Dissertation: Multiplicative Data Perturbation for Privacy Preserving Data Mining Kun Liu, Doctor of Philosophy, 2007 Dissertation directed by: Dr. Hillol Kargupta Associate Professor Department of Computer Science and Electrical Engineering Recent interest in the collection and monitoring of data using data mining technology for the purpose of security and business-related application...

Title of Dissertation: Privacy Preserving Distributed Data Mining based on Multi-objective Optimization and Algorithmic Game Theory Kamalika Das, Doctor of Philosophy, 2009 Thesis directed by: Dr. Hillol Kargupta Professor Department of Computer Science and Electrical Engineering Use of technology for data collection and analysis has seen an unprecedented growth in the last couple of decades. I...