The sulfurous acid ester, trans-sulfurous acid allyl ester 3-allylsulfanyl-allyl ester 8, along with two known thiosulfinates was isolated from the aqueous ethanol extract of garlic (Allium sativum). The chemical structure of 8 was determined on the basis of spectroscopic data including high resolution mass and two-dimensional NMR techniques. All of these compounds induced methemoglobin formati...

BACKGROUND: Garlic (Allium sativum) is known for its anti-bacterial properties, but information on its effects against bacteria species that are important in fish diseases is scarce. OBJECTIVES: The aim of this research was to use garlic as a natural product to improve the aquatic animal health status so as to compensate the demand for environment-friendly products for sustainable aquacultur...

Garlic extracts have been shown to decrease drug exposure for saquinavir, a P-glycoprotein and cytochrome P450 3A4 substrate. In order to explore the underlying mechanisms and to study the effects of garlic on pre-systemic drug elimination, healthy volunteers were administered garlic extract for 21 days. Prior to and at the end of this period, expression of duodenal P-glycoprotein and cytochrom...

Although extracts of garlic inhibit cholesterol biosynthesis in cultured hepatocytes, the inhibitory components of garlic and the site or sites of inhibition in the cholesterol biosynthetic pathway have not been established. To elucidate potential mechanisms of inhibition, we examined the effect of fresh garlic extract and 16 water- or lipid-soluble compounds derived from garlic on purified rec...

helminths infections are chronic illness in human being and cattle. the use of alternate drugs has been a remedial measure against the resistant strains of helminth parasites, as well as means of reducing the cost of controlling diseases caused by helminthes. pseudocedrelakotschyi is a medicinally valuable plant and possesses various pharmacological properties. p. kotschyi has been traditionall...

objective: garlic is a plant has been used as a flavor, and anti-microbial and anti-diarrheal agent. infectious bronchitis virus (ibv) is a coronavirus. the available vaccines against ibv cannot cover new variants. this study evaluated the inhibitory effects of garlic extract on ibv.  materials and methods: the constituents of garlic extract were detected by gas chromatography. this study was d...

Objective: Garlic (Allium sativum. L) plays an important dietary role, as well as medicinal, for centuries. Even today the use of garlic is widespread and growing. The present study investigated the effect of garlic extract and glibenclamide on biochemical parameters, enzyme activities, and reduced glutathione (GSH) content in the liver as well as on pancreas tissue in alloxan-induced diabetic ...

The increasing prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in hospitals and the community has led to a demand for new agents that could be used to decrease the spread of these bacteria. Topical agents such as mupirocin have been used to reduce nasal carriage and spread and to treat skin infections; however, resistance to mupirocin in MRSAs is increasing. Allicin is the main...