Thirteen human subjects scheduled for elective anterior segment eye surgery received hourly 2% voriconazole eye drops 4 hours presurgery. No side effects were reported. Significantly, the voriconazole concentration in the aqueous humor of the eye was similar to that reported for the 1% voriconazole solution, suggestive of concentration-independent absorption.

Zinc concentrations in aqueous humour and serum were determined by means of atomic absorption spectrophotometry in 11 patients with cataract. The zinc content of the aqueous humour was found to be considerably lower than the corresponding serum values. From this finding it is suggested that aqueous humour does not serve as a likely route of delivery of zinc to the cornea.

PURPOSE The aim was to report the aqueous humor moxifloxacin concentration and proteome profile of an individual with bilateral uveitis-like syndrome with pigment dispersion. METHODS Multiple reactions monitoring mass spectrometry quantified the aqueous concentration of moxifloxacin in the affected individual. Shotgun proteomic analysis performed via liquid chromatography tandem mass spectrom...

for primary open angle glaucoma (POAG), and lowering IOP is currently the only treatment available for the management of POAG. The conventional route of aqueous humor outflow through trabecular meshwork (TM) and Schlemm’s canal (SC) is generally thought to be the major pathway for the drainage of aqueous humor from the eye. Impaired drainage through the conventional outflow pathway is believed ...

Glucose concentrations of in vitro human aqueous humor (HAH) samples from cataract patients were determined using 785 nm Raman spectra and partial least squares (PLS) calibration. PLS models were created from spectra of prepared calibration solutions rather than aqueous humor samples. Spectra were obtained with an excitation energy (100 mW for 150 s), which was higher than can be applied in viv...

OBJECTIVE To observe the influence of the the transforming growth factor β1 (TGF-β1) eye drops on rabbit aqueous humor TGF-β1 concentration, and to analyze the best drug concentration. METHODS A total of 30 New Zealand white rabbits were randomly divided into 5 groups with 6 in each. Rabits in control group had PBS eye drops, group A, B, C, D adopted TGF-β1 eye drops at 0.5, 1.0, 2.0, 4.0 mg/...

Matrix metalloproteinases (MMPs) are a group of endopeptidases with the role of reorganizing the extracellular matrix of cells through the body. In aqueous humor MMPs have an important role in turnover regulation by acting on the constant remodeling of the trabecular mesh keeping at a constant level the trabecular resistance for a good aqueous humor outflow and consequently of the intraocular p...

purpose : fluoroquinolones are widely used antibiotic for prophylaxis of intra and postoperative infections in individuals undergoing cataract surgery. this study was designed to assess the penetration of ciprofloxacin into the ocular aqueous humor (topical only versus topical and oral administration). methods : studied population (n=47) consisted of two groups: group one (n=26) and group two (...

PURPOSE Based on contact lens-induced stromal acidification of the cornea, it has been suggested that the corneal epithelial and endothelial cells also become acidotic during contact lens wear. This alleged acidification may have a role in altered cell appearance and metabolism during contact lens wear. This study investigated the effects of anoxia, carbon dioxide retention, and contact lens ga...

PURPOSE The aim of the study reported in this article was to determine the presence and quantitative differences of matrix metalloproteinase-2 (MMP-2), its tissue inhibitor (TIMP-2) and transforming growth factor beta 1 (TGF-β1) in the aqueous humor and serum samples of patients with pseudoexfoliation (PEX) syndrome. METHODS Aqueous humor and serum samples were collected from 32 patients with...