Olmesartan medoxomil (OLM) is an angiotensin II receptor blocker (ARB) antihypertensive agent administered orally that has absolute bioavailability of only 26% due to the poor aqueous solubility (7.75 μg/ml). The aim of the present investigation was to develop a self-microemulsifying drug delivery system (SMEDDS) to enhance the oral absorption of OLM. The solubility of OLM in various oils, surf...

The purpose of this research is to design and formulate the Self-micro emulsifying drug delivery system (SMEDDS) poorly water-soluble Sertraline Hydrochloride (SRT). SRT commonly used selective serotonin reuptake inhibitor for management a number depressive disorders. Its applicability limited because extensive metabolism poor oral bioavailability 44 %. Solubility in different vehicles determin...

Nimodipine (NMP), a Ca channel blocker, has a low oral bioavailability due to poor solubility and insufficient dissolution rate. In order to improve the same, various techniques were employed viz., evaporative precipitation into aqueous solution (EPAS), spherical agglomeration (SA) and solid dispersion using solvent evaporation and meltmixing. Formulations so prepared were characterised by diff...

Objective: Chlorzoxazone (CLZ) is centrally acting skeletal muscle relaxant. It is insoluble in water, so employed for the formation of solid dispersions (SD) as a means to enhance the dissolution rate, and carrier selected was polyethylene glycol 6000 (PEG 6000). Methods: The SDs were prepared by different methods and characterized by in vitro drug release, drug content, fourier transform infr...

Chlordiazepoxide, a member of the 1, 4-benzodiazepine, showing poor aqueous solubility and dissolution rate in water, so the present work was focused to prepare the microspheres of Chlordiazepoxide to improve its solubility and dissolution; using chitosan with different drug: polymer ratio by spray-drying technique. The effect of different drug: polymer ratio on the solubility and dissolution o...

G. Ma, B. S. Levine, D. J. Lavrich Merck & Co., Inc. Purpose Amorphous solid dispersions have been increasingly used to enhance the bioavailability for poorly soluble drugs. Dissolution method development for these formulations has faced challenges due to their unstable super saturation state in aqueous media. Whether the dissolution sink condition should be based on API crystalline solubility ...

In this study, a novel mesoporous silica nanoparticles drug carrier contributes to improving the solubility, dissolution, and the oral bioavailability of apigenin (AP). The apigenin of solid dispersion of mesoporous silica nanoparticles (AP-MSN) was prepared by physical absorption method and also, in-vitro drug release and in-vivo bioavailability performance were evaluated. Based on its solubil...

Solubility is the process of dissolution of solid in liquid phase to give a homogenous system and is one of the important parameter to achieve desired concentration of drug in systemic circulation for pharmacological response. Dissolution rate of poorly water-soluble drugs is rate limiting step for its bioavailability so increase in bioavailability is the major challenging task in drug developm...

The main purpose of the present investigation is to enhance the solubility and bioavailability of poorly watersoluble atorvastatin calcium (ATR) through the self nanoemulsifying drug delivery system (SNEDDS).The components for self-nanoemulsion were identified by solubility studies and tendency for self-emulsification in various excipients. Sefsol 218, Cremophor RH 40 and Propylene glycol were ...

The intrinsic dissolution rate and solubility of carbamazepine was measured in aqueous solutions of sodium lauryl sulfate (SLS) prepared with two different grades of purity, 95 and 99%, and 95% SLS in 0.15 M NaCl to determine the effect of surface-active impurities and electrolytes. Four significant observations resulted from this work: (1) the equilibrium coefficients calculated from the solub...