نتایج جستجو برای: arrhythmogenicity

تعداد نتایج: 246  

Journal: :American journal of physiology. Heart and circulatory physiology 2014
Daniel R Gonzalez Adriana V Treuer Guillaume Lamirault Vera Mayo Yenong Cao Raul A Dulce Joshua M Hare

Duchenne muscular dystrophy may affect cardiac muscle, producing a dystrophic cardiomyopathy in humans and the mdx mouse. We tested the hypothesis that oxidative stress participates in disrupting calcium handling and contractility in the mdx mouse with established cardiomyopathy. We found increased expression (fivefold) of the NADPH oxidase (NOX) 2 in the mdx hearts compared with wild type, alo...

Journal: :Circulation. Arrhythmia and electrophysiology 2017
Nicolò Salvarani Ange Maguy Stefano A De Simone Michele Miragoli Florian Jousset Stephan Rohr

BACKGROUND TGF-β1 (transforming growth factor-β1) importantly contributes to cardiac fibrosis by controlling differentiation, migration, and collagen secretion of cardiac myofibroblasts. It is still elusive, however, to which extent TGF-β1 alters the electrophysiological phenotype of myofibroblasts and cardiomyocytes and whether it affects proarrhythmic myofibroblast-cardiomyocyte crosstalk obs...

2017
Dominic G. Whittaker Haibo Ni Aziza El Harchi Jules C. Hancox Henggui Zhang

Gain-of-function mutations in KCNJ2-encoded Kir2.1 channels underlie variant 3 (SQT3) of the short QT syndrome, which is associated with atrial fibrillation (AF). Using biophysically-detailed human atria computer models, this study investigated the mechanistic link between SQT3 mutations and atrial arrhythmogenesis, and potential ion channel targets for treatment of SQT3. A contemporary model o...

2016
Thomas D. Gossios Georgios K. Efthimiadis Theodoros D. Karamitsos Thomas Zegkos Vasilios G. Athyros Haralambos I. Karvounis

Hypertrophic cardiomyopathy, the most common inherited cardiomyopathy is well known to be the leading cause of sudden cardiac death in young people. However, amongst the population of patients, a small subset bears increased risk of sudden cardiac death and would benefit from implantation of a defibrillator, currently recognized utilizing a series of established risk factors. This risk stratifi...

2016
Zachary M. Harris Alvaro Alonso Thomas P. Kennedy

Stress (Takotsubo) cardiomyopathy is a form of reversible left ventricular dysfunction with a heightened risk of ventricular arrhythmia thought to be caused by high circulating catecholamines. We report a case of stress cardiomyopathy that developed during severe alcohol withdrawal successfully treated with dexmedetomidine. The case involves a 53-year-old man with a significant history of alcoh...

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