Increasing interests have been raised toward the potential applications of biodegradable poly(lactic-co-glycolic acid) (PLGA) coatings for drug-eluting stents in order to improve the drug delivery and reduce adverse outcomes in stented arteries in patients. This article presents a mathematical model to describe the integrated processes of drug release in a stent with PLGA coating and subsequent...

BACKGROUND AND PURPOSE Neuroprotection with brain-derived neurotrophic factor (BDNF) requires direct injection into the brain owing to poor transport of the neurotrophin through the blood-brain barrier (BBB) in vivo. The present studies investigate whether BDNF alone or conjugated to a BBB drug targeting system is neuroprotective in focal, reversible brain ischemia after delayed intravenous adm...

conclusions: the reduction of propofol injection pain was observed by using medications (in comparison with normal saline), but it was more significant in groups g and l. moreover, hypotension was higher in groups s and g and it was lessened in group p. patients and methods: this is an interventional study containing 336 patients underwent elective orthopedic surgeries in educational hospitals ...

Disposition characteristics of various anticancer drugs in a tissue-isolated tumor preparation were studied in Walker 256 carcinosarcoma-bearing rats using an in situ single-pass vascular perfusion technique. Three anticancer drugs, 5-fluorouracil, mitomycin C, and Adriamycin, and two lipophilic prodrugs of mitomycin C were tested in the tumor preparation perfused with Tyrode's solution contain...

Sixty six patients undergoing elective valve surgery were randomized to receive rocuronium bromide 0.6 mg/Kg (Group R, n=22), pancuronium bromide 0.1 mg/Kg (Group P, n= 22) and vecuronium bromide 0.1 mg/Kg (Group V, n=22), Measurements of heart rate and arterial pressure (systolic, diastolic and mean) were noted at the following stages: 1) baseline when haemodynamics were stable for 2 minutes a...

pharmacokinetics of ceftriaxone was studied in buffalo calves (bubalus bubalis) after single intravenousand intramuscular administration of 10 mg/kg body weight. the drug concentrations in plasma samples weremeasured by high performance liquid chromatography with uv detection. following intravenousadministration, the drug was rapidly distributed (cpo: 106.5 ± 9.64 μg/ml; t1/2α: 0.09 ± 0.01 h; v...