Objective—To develop and assess a simple, inexpensive method for ascertaining the placement of intra-articular injections for knee osteoarthritis Methods—During a one year period patients with “dry” osteoarthritis of the knee who received intra-articular therapy were tested by air-arthrography. Along with triamcinolone and lignocaine (lidocaine), 5 ml of air was injected into the joint. On subs...

Despite its widespread existence, there are relatively few drugs that can inhibit the progression of osteoarthritis (OA). Syndecan-4 (SDC4) is a transmembrane heparan sulfate proteoglycan modulates cellular interactions with extracellular matrix. Upregulated SDC4 expression in articular cartilage chondrocytes correlates OA progression. In present study, we treated osteoarthritic to elucidate ro...

Objective: To investigate the ability of high resolution grey scale sonography (GSS) and power Doppler sonography (PDS) to assess short term soft tissue changes induced by intra-articular steroid injection in the small joints of patients with chronic synovitis. Methods: 20 patients with clinically active synovitis of a small joint unresponsive to systemic drug treatment underwent a sonographic ...

In an attempt to test the accuracy of the intra-articular injection treatment of coxarthritis, as used by Waugh (1945), Crowe (1944), and many other investigators; hip-joints of 33 cadavers were injected (Dobson, 1948) with dye solution which jellified on cooling. The technique of injection was similar to that applied in living patients undergoing treatment for osteo-arthritis of the hip. In 19...

OBJECTIVE IA injections of SIJs with corticosteroids are often performed in patients suffering from low back pain due to active sacroiliitis. However, SIJ injections are technically demanding, and therefore the clinical outcome of ultrasound-guided corticosteroid SIJ injections was analysed in relation to the accuracy of the injection. METHODS Ultrasound-guided injections were performed with ...

OBJECTIVE To investigate the ability of high resolution grey scale sonography (GSS) and power Doppler sonography (PDS) to assess short term soft tissue changes induced by intra-articular steroid injection in the small joints of patients with chronic synovitis. METHODS 20 patients with clinically active synovitis of a small joint unresponsive to systemic drug treatment underwent a sonographic ...

OBJECTIVE This study aimed to evaluate the effect of one dose of intra-articular injection of (PRP) in the knee joint on a specific osteoarthritis (OA) serum biomarker of cartilage degeneration, Collagen 2-1 (Coll2-1), over a short period of 3 months. The aim extended to clarify the effect of PRP on the functional status of the osteoarthritic knee joint. MATERIAL AND METHODS Sixty patients wi...

OBJECTIVE To evaluate the safety and efficacy of a single intra-articular injection of 2% hyaluronic acid (HA)+mannitol in symptomatic knee osteoarthritis (KOA). MATERIAL AND METHODS Pilot, multicentre, open, non-comparative study performed in eighty patients with painful KOA, of whom 79 completed the study. They received one injection of 2ml of 2% HA+0.5% mannitol (Day 0) and were followed-u...

BACKGROUND Patients with groin, hip and pelvic pain but normal findings on MRI and minimal changes on x-ray can be a diagnostic problem. This paper looks at the arthroscopic findings of patients who have had hip pain and a positive response to an intra-articular anaesthetic but have non-contributory imaging. We hypothesized that standard MRI's were missing significant pathology and if there was...

OBJECTIVES To evaluate the effectiveness of a single intra-articular injection of hylan G-F 20 (Synvisc) for symptomatic first metatarsophalangeal joint (MTPJ) osteoarthritis (OA). METHODS Participants (n = 151) with symptomatic first MTPJ OA were randomly allocated to receive up to 1 ml intra-articular injection of either hylan G-F 20 or placebo (saline). Participants and assessors were blin...