Over the last 15 academic volumes of publication of the Journal of Evaluation in Clinical Practice (JECP), the Editor, with an extensive number of colleagues internationally, has called continuously for the advocates of evidence-based medicine (EBM) to answer their critics in an open, intellectually rigorous and collegiate manner [1–14]. Now, some of the leading protagonists of EBM – Benjamin D...

Current literature on pulmonary fibrosis induced in animal models highlights the need of an accurate, reliable and reproducible histological quantitative analysis. One of the major limits of histological scoring concerns the fact that it is observer-dependent and consequently subject to variability, which may preclude comparative studies between different laboratories. To achieve a reliable and...

Molecular hydrogen (H(2)) is an efficient antioxidant that diffuses rapidly across cell membranes, reduces reactive oxygen species (ROS), such as hydroxyl radicals and peroxynitrite, and suppresses oxidative stress-induced injury in several organs. ROS have been implicated in radiation-induced damage to lungs. Because prompt elimination of irradiation-induced ROS should protect lung tissue from...

Background Systemic scleroderma (SSc) is an autoimmune disease characterized by a wide range of clinical manifestations. One the main targets this pathology pulmonary system. In turn, SSc-associated damage lung structures significant negative impact on survival and quality life patients. Objectives Therefore, we aimed to assess possible favorable influence vitamin D3 (VD3) α-tocopherol acetate ...

Abstract Introduction Conservative estimates suggest that the cost of poor medication adherence (MA) to healthcare systems in UK is close £800Mn annually, however figures may be as high £920Mn £224Bn across larger parts Europe and US.(1) This attributed relationship between MA an increased risk hospital admission.(2) Often, cases are preventable hence present opportunity for avoidable costs if ...

Correspondence to Alessio Accardi: a l e s s i o a c c a r d i @ u i o w a . e d u The ability to sense the metabolic state of a cell and tune its electrical activity through the direct or indirect modulation of ion transport systems by ATP is essential in a multitude of physiological processes in both excitable and nonexcitable cells. For example in pancreatic cells an increase in the ATP leve...

other organs: their epidemiology and implications for clinical practice, Am Rev Respir Dis 114:187-227, 1976 3 Ashcroft T, Heppeiston AG: The optical and electron microscopic determination of pulmonary asbestos fiber concentration and its relation to the human pathological reaction. J Clin Path 28:224-234, 1973 4 Smoking and Health: A report of the Surgeon General. Washington, D.C., US Departme...

An early report of syphilis from the Caribbean area suggested the rarity of this disease as a cause of mental illness (Ireland, 1892). More recently a decreasing incidence of neurosyphilis was noted among racially similar persons in Uganda by Billington (1966), who attributed to penicillin the remarkable fall over the 20-year period reviewed. The low incidence in developed countries probably ha...

Based initially on their prominence in the squid giant axon, their useful pharmacology, and subsequently on being the first cloned K channels, voltage-gated K (Kv) channels have received the lion’s share of attention to their biophysical properties. Kv and Ca-activated K channel kinetics and gating mechanisms have been analyzed, and modeled, in exquisite detail (Hille, 2001). Inward rectifier K...