The present study investigated the capacity of formulated Berberis vulgaris extract/β-cyclodextrin to protect liver against CCl(4)-induced hepatotoxicity in mice. Formulated and non-formulated extracts were given orally (50 mg/kg/day) to mice for 7 days and were then intra-peritoneally injected with 1.0 mL/kg CCl(4) on the 8th day. After 24 h of CCl(4) administration, an increase in the levels ...

To examine if a potentized homeopathic drug, Natrum Sulphuricum 200 (Nat Sulph-200) has protective potentials against hepatocarcinogenesis, liver tumors were induced in mice through chronic feeding of P-dimethylaminoazobenzene (p-DAB; initiator of hepatocarcinogenesis) and phenobarbital (PB; promoter). Mice were divided into five sub-groups: fed normal low protein diet (Gr. I, normal control); ...

Pesticides intoxication has been implicated in many toxic diseases, and agricultural adjuvants including polyethylene glycols are used in a variety of applications including industrial manufacturing. The aim of this study was to analyze the effect of PEG-600 on the biochemical toxic effects of malathion, imiprothrin and imidacloprid on the basis of the determined LD50 values on the quails (Cotu...

Effect of caffeine-coconut products interactions on induction of drug-metabolizing enzyme in Wistar albino rats was studied. Twenty rats were randomly divided into four groups: The control group (1) received via oral route a placebo (4.0 ml of distilled water). Groups 2 to 4 were treated for a 14-day period with 50 mg/kg body weight of caffeine, 50 mg/kg body weight of caffeine and 50 mg/kg bod...

BACKGROUND Changes in the activities of plasma alanine amino transferase (ALT), aspartate amino transferase (AST), gamma glutamyl transferase (GGT), and alkaline phosphatase (ALP) are used to assess the functional state of the liver. Significant increase in the activities of these enzymes commonly indicates the hepatotoxicity of chemical agent(s) in the body. Exposure of male and female rats to...

Liver transaminases: aspartate amino transferase (AST) and alanine amino transferase (ALT) are biomarkers of liver damage in a patient. High-density lipoprotein (HDL) and low-density lipoprotein (LDL) are from the five significant groups of lipoproteins which allow lipids to be transported within the water-based blood flow. Multiple plants are used for the treatment of liver diseases. Therefore...

Higher fat and lower carbohydrate and amino acid oxidation are observed in women compared with men during endurance exercise. We hypothesized that the observed sex difference is due to estrogen and that menstrual cycle phase or supplementation of men with 17beta-estradiol (E(2)) would coordinately influence the mRNA content of genes involved in lipid and/or carbohydrate metabolism in skeletal m...

In our previous paper we demonstrated the influence of Rauwolfia vomitoria root bark extract on cardiac enzymes of normal Wistar rats and the effectiveness of this root bark as a source of antihypertensive agent, as determined by the marker enzymes, would be a useful index for the toxicity of this plant in clinical application. In this paper we present the results of the effect of Rauwolfia vom...