In this study, 1717 fungal clinical isolates causing invasive fungal infections were evaluated against nine antifungal agents using Clinical and Laboratory Standards Institute (CLSI) reference broth microdilution methods. The isolates comprised 1487 Candida spp., 109 Aspergillus spp., 86 non-Candida yeasts (including 52 isolates of Cryptococcus neoformans) and 35 rare moulds obtained during 201...

OBJECTIVES The activity in vitro of terbinafine against 442 clinical isolates of several species of filamentous fungi was analysed. METHODS A broth microdilution test was carried out following the National Committee for Clinical Laboratory Standards reference method, with modifications described previously. RESULTS The geometric mean (GM) of MICs of terbinafine for non-Aspergillus fumigatus...

The in vitro activity of thimerosal versus those of amphotericin B and natamycin was assessed against 244 ocular fungal isolates. The activity of thimerosal against Fusarium spp., Aspergillus spp., and Alternaria alternata was 256 times, 512 times, and 128 times, respectively, greater than that of natamycin and 64 times, 32 times, and 32 times, respectively, greater than that of amphotericin B....

Feline upper respiratory tract aspergillosis (URTA) is an emerging infectious disease. The aims of this study were: (1) to assess the diagnostic value of detection of Aspergillus-specific antibodies using an agar gel double immunodiffusion (AGID) assay and an indirect immunoglobulin G (IgG) ELISA; and (2) to determine if an aspergillin derived from mycelia of Aspergillus fumigatus, Aspergillus ...

Recent studies have shown that there are multiple clinically important members of the Aspergillus section Fumigati that are difficult to distinguish on the basis of morphological features (e.g., Aspergillus fumigatus, A. lentulus, and Neosartorya udagawae). Identification of these organisms may be clinically important, as some species vary in their susceptibilities to antifungal agents. In a pr...

OBJECTIVES Fungal empyema thoracis (FET) is a rare life-threatening infection. We sought to describe the clinical characteristics of FET in a large academic cancer center. METHODS We conducted a retrospective chart review of all cancer patients who had a fungal isolate from the pleural fluid culture between 1/2005 and 8/2013. RESULTS A total of 106 fungal isolates were identified in 97 pati...

Posaconazole is a highly lipophilic drug. It is one of the more recent triazole antifungals critical in the treatment of invasive mycoses [1]. It disturbs fungi growth by inhibiting cytochrome P450 lanosterol 14α-demethylase (CYP51A1) that leads to blockage of ergosterol synthesis in the fungal cell membranes. The end result of this reaction is the increase of fungi cell membrane permeability a...

in this study, 42 samples of silage were collected in qaemshahr city in iran during fall 2011. samples were tested by competitive elisa for total aflatoxins. seven samples (16.7%) (mean±se:1.24) from 42 silage samples were positive with total aflatoxin (1.1-27.3 ppb) in nov., dec. and oct. the highest contamination was observed in oct., three samples (21.4%) from 14 samples were contaminated wi...