OBJECTIVE This study aimed to validate the statistical evidence from the genome-wide association study (GWAS) as true-positive and to better understand the effects of the glycophorin C (GYPC) gene on serum hemoglobin traits. METHODS Our initial GWAS revealed the presence of two single nucleotide polymorphisms (SNPs) (ASGA0069038 and ALGA0084612) for the hemoglobin concentration trait (HGB) in...

conclusions although we found an association between myh9 gene polymorphism and urinary albumin excretion, the results did not show a significant association between myh9 polymorphism (rs4821481) and risk of dn in iranian diabetic patients. background myosin heavy chain 9 (myh9) gene polymorphisms have been implicated in different types of renal disease, as well as in nephropathy attributed to ...

introduction: association between single-nucleotide polymorphisms (snps) in mu opioid receptor gene and drug addiction has been shown in various studies. here, we have evaluated the existence of polymorphisms in exon 3 of this gene in iranian population and investigated the possible association between these mutations and opioid addiction.  methods: 79 opioid-dependent subjects (55 males, 24 fe...

We develop a Split Reactive Brownian Dynamics (SRBD) algorithm for particle simulations of reaction-diffusion systems based on the Doi or volume reactivity model, in which pairs of particles react with a specified Poisson rate if they are closer than a chosen reactive distance. In our Doi model, we ensure that the microscopic reaction rules for various association and dissociation reactions are...

this study was designed to find out the impact of the variable number of tandem repeats (vntr) of the tumor necrosis factor receptor 2 (tnfrsf1b) on pulmonary tuberculosis (ptb) risk in an iranian population. this case-control study was done on 159 ptb patients and 158 healthy subjects. bi-allelic tnfrsf1b vntr was genotyped by polymerase chain reaction. logistic regression analysis revealed no...

granulomatous response in association with breast cancer and within the cancer draining lymph nodes is an extremely rare phenomenon. granulomatous inflammation is an immune response commonly seen against infectious agents and certain non-neoplastic conditions. the etiopathogenesis of granulomas associated with malignancies is not clear but it may be because of an immunologic reaction to tumour ...