This article summarizes perspectives on how reactive oxygen species (ROS) and redox signaling mechanisms participate in regulating vascular smooth muscle function that have resulted from our studies over the past 25 years in areas including oxygen sensing and the regulation of cGMP production by soluble guanylate cyclase (sGC) that were presented in the Robert M. Berne Distinguished Lectureship...

Today power consumption is considered to be one of the important issues. Therefore, its reduction plays a considerable role in developing systems. Previous studies have shown that approximately 50% of total power consumption is used in cache memories. There is a direct relationship between power consumption and replacement quantity made in cache. The less the number of replacements is, the less...

Soil salinity is a crucial environmental constraint which limits biomass production at many sites on a global scale. Saline growth conditions cause osmotic and ionic imbalances, oxidative stress and perturb metabolism, e.g., the photosynthetic electron flow. The plant ability to tolerate salinity is determined by multiple biochemical and physiological mechanisms protecting cell functions, in pa...

Metaplasticity regulates the threshold for modification of synaptic strength and is an important regulator of learning rules; however, it is not known whether these cellular mechanisms for homeostatic regulation of synapses contribute to particular forms of learning. Conditional ablation of mGluR5 in CA1 pyramidal neurons resulted in the inability of low-frequency trains of afferent activation ...

It is argued that in order to efficiently tackle complex problems, user and support system should intimately interact, complementing each other's weaknesses. Strengths and limitations of human intelligence, respectively computer intelligence, can be derived from the mechanism of associative, respectively “chunk-based”, memory. A good interactive interface should hence allow one to translate bet...

The redox regulation of Janus kinases (JAKs) is a complex subject. Due to other redox-sensitive kinases in the kinome, redox-sensitive phosphatases, and cellular antioxidant systems and reactive oxygen species (ROS) production systems, the net biological outcomes of oxidative stress on JAK-dependent signal transduction vary according to the specific biological system examined. This review begin...