We use the generalized singular value decomposition (GSVD), formulated as a comparative spectral decomposition, to model patient-matched grades III and II, i.e., lower-grade astrocytoma (LGA) brain tumor and normal DNA copy-number profiles. A genome-wide tumor-exclusive pattern of DNA copy-number alterations (CNAs) is revealed, encompassed in that previously uncovered in glioblastoma (GBM), i.e...

The aim of the present study was to identify the common molecular mechanisms of multiple glioma subtypes, including astrocytoma, glioblastoma and oligodendroglioma, in addition to the specific mechanisms of different types. The gene expression profile set GSE4290 was downloaded from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) from three types of glioma, relative ...

OBJECTIVE To examine the association between fragile X mental retardation protein (FMRP) expression and astrocytoma characteristics. METHODS Pathologic grade and expressions of glial fibrillary acidic protein (GFAP), Ki67 (proliferation marker), and FMRP were determined in astrocytoma specimens from 74 patients. Kaplan-Meier survival analysis was undertaken. Pathologic grade and protein level...

Astrocytoma is the most common glioma, accounting for half of all primary brain and spinal cord tumors. Late detection and the aggressive nature of high-grade astrocytomas contribute to high mortality rates. Though many studies identify candidate biomarkers using high-throughput transcriptomic profiling to stratify grades and subtypes, few have resulted in clinically actionable results. This sh...

OBJECTIVE Extracranial bone metastases from astrocytoma are rare and frequently detected as part of multiorgan metastases. It is extremely rare for astrocytoma to have extracranial bone metastases alone. The importance of whole-body fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) imaging in evaluating extracranial metastasis (ECMs) has not been described effecti...

The astrocytoma cancer represents CNS neoplasms in which the predominant cell type is derived from an immortalized astrocyte. The genomewide analysis of glioma identified somatic mutation at codon 132 of the IDH1 gene which encodes NADP+ dependent isocitrate dehydrogenase. Further studies indicated that patients with somatic, heterozygous R132H mutation have distinct clinical characteristic: yo...

The overexpression of eyes absent (Eya) 2 has been found in several human cancers. However, its biological roles and clinical significance in human astrocytoma have not yet been explored. This study investigated the clinical significance and biological roles of Eya2 in human astrocytoma tissues and cell lines. Using immunohistochemistry, we found Eya2 overexpression in 33 out of 90 (36.7%) astr...

A Study of Platelet-Derived Growth Factor and Its Ligand among Patients with Glioblastoma Astrocytoma in Imam Khomeini Hospital Complex, Tehran

currently cancer is considered as one of the main factors of mortality globally. many chemicals in our environment can cause genetic mutations and are potentially responsible for millions of cancer-related deaths. nowadays the scientists are looking for food materials which can potenthially prevent the cancer occurrence. the purpose of this research is to examine antimutagenicity and anticancer...

Abstract Background Evidence suggests that smaller residual tumor volumes after initial surgery are associated with longer survival in patients astrocytoma, IDH-mutant, grade II. For IDH-mutant glioma of higher but also for oligodendroglioma, and 1p/19q codeleted, the impact on more is unclear. This could be related to limited follow-up oligodendroglioma typically have long overall survival. We...