Benzofused seven-membered heterocycles such as 1,4-benzo[e]diazepines (1,4-BZDs) and 1,4-benzo[e]oxazepines (1,4-BZOs) were efficiently synthesized by Rh-catalyzed hydrofunctionalization of internal alkynes allenes in good to excellent yields. The asymmetric hydroamination (aminomethyl)anilines gave rise 3-vinyl-1,4-BZDs with enantioselectivities. Orthogonal N-deprotection 1,4-BZDs allowed an e...

This paper explores the equilibrium correspondence of a dynamic quality ladder model with entry and exit using the homotopy method. This method is ideally suited for systematically investigating the economic phenomena that arise as one moves through the parameter space and is especially useful in games that have multiple equilibria. We briefly discuss the theory of the homotopy method and its a...

We consider an incumbent who operates in two independent markets and has private information about his production cost. In one of the markets, there is a potential entrant o¤ering a di¤erentiated product. The most reasonable perfect bayesian equilibrium is either the least cost separating equilibrium or the pooling equilibrium where both types of incumbents set the low cost monopoly prices. The...

Biological lipid membranes are predominantly asymmetric. In the plasma membranes of eukaryotic cells, for example, there is an abundance of phosphatidylcholine and sphingomyelin in the outer leaflet while aminophospholipids are primarily in the cytosolic leaflet. The biological importance of asymmetric lipid bilayers has motivated many studies using model systems, such as planar bilayers, suppo...

Abstract Inspired by the phenomenon of stone-skipping in life, problem continuous water-skipping trans-media vehicles is widely concerned, which characterized multiphase flow-solid coupling, dynamic boundary, liquid surface fragmentation and high impact loads. Based on Moving Particle Semi-implicit numerical method, this paper investigates disc’s motion characteristics variation, focusing influ...

The composition of the outer membrane in Gram-negative bacteria is asymmetric, with the lipopolysaccharides found in the outer leaflet and phospholipids in the inner leaflet. The MlaC protein transfers phospholipids from the outer to inner membrane to maintain such lipid asymmetry in the Mla pathway. In this work, we have performed molecular dynamics simulations on apo and phospholipid-bound sy...

The aim of the present study was to design an asymmetric membrane capsule, an osmotic pump-based drug delivery system of ethyl cellulose for controlled release of terbutaline sulphate. asymmetric membrane capsules contains pore-forming water soluble additive, sorbitol in different concentrations in the capsule shell membrane, which after coming in contact with water, dissolves, resulting in an ...