Here, we show that the anaplastic thyroid carcinoma (ATC) features the up-regulation of a set of genes involved in the control of cell cycle progression and chromosome segregation. This phenotype differentiates ATC from normal tissue and from well-differentiated papillary thyroid carcinoma. Transcriptional promoters of the ATC up-regulated genes are characterized by a modular organization featu...

BACKGROUND Anaplastic thyroid cancer (ATC) is a rare, lethal disease associated with a median survival of 6 months despite the best multidisciplinary care. Surgical resection is not curative in ATC patients, being often a palliative procedure. Multidisciplinary care may include surgery, loco-regional radiotherapy, and systemic therapy. Besides conventional chemotherapy, multi kinase-targeted in...

BACKGROUND Anaplastic thyroid carcinoma (ATC) is an uncommon thyroid malignancy with a poor prognosis. American Thyroid Association (ATA) guidelines acknowledge the complexity of airway management in these patients. We studied our local experience with the aim of providing guidance in airway management in ATC. METHODS Patients with histologically confirmed ATC from January 2004 to December 20...

Electric power industries throughout the world have been restructured to introduce competition among the market participants and bring several competitive opportunities. Open access to the transmission system places an emphasis on the intensive use of the interconnected network reliably, which requires knowledge of the network capability. Available Transfer Capability (ATC) is a measure of the ...

Anaplastic thyroid carcinoma (ATC) is one of the most aggressive human cancers. Actually, ATC is refractory to conventional therapies, including surgery, chemotherapy, radiotherapy, and radioiodine ((131)I) therapy. Accordingly, genetic and molecular characterizations of ATC have been frequently and periodically reviewed in order to identify potential biological markers exploitable for target t...

The Acute Toxic Class (ATC) Methods for the oral, dermal and inhalation routes were developed as alternatives to the respective LD/LC50 Tests. The ATC Methods use at least 40% (and up to 90%) fewer animals and their reliability with respect to classification probabilities into one of several toxicity classes is in the same order of magnitude or even better in comparison to the LD/LC50 Tests. Th...

To the Editor: In “Collision tumors of the thyroid: A case report and review of the literature,” Ryan et al describe an interesting case of an 88-year-old woman with airway compromise because of a thyroid mass. This patient also had widespread metastases on presentation. Surgical pathology demonstrated a papillary thyroid carcinoma and a squamous cell carcinoma. This case is a common scenario t...

cent initiatives involving social psychology applications in the aviation world have redoubled the interest in ept of teams and teamwork. The importance of teamwork in airline cockpits, hailed as cockpit (or crew-) management (CRM), has been recognized for a relatively long time. It is also widely agreed that extensive ctive interaction among participants in the National Airspace System (NAS), ...

Technetium-99m-antimony trisulfide colloid ((99m)Tc-ATC) was investigated with varying specific activity in the rat lymphatic system, as well as its binding to rat blood cells in vitro. Low, moderate and high doses of (99m)Tc-ATC were subdermally injected into tails of rats (n=3) and 30min later whole body lymphoscintigraphic images were acquired. (99m)Tc-ATC was incubated for 30min at 37°C wit...

Radioactive-iodine (RAI) therapy is typically unprevailing as anaplastic thyroid cancer (ATC) management, owing to the decrease in the endogenous sodium iodide symporter (NIS) expression. Therefore, new strategies for NIS re-induction are required to improve the efficacy of RAI therapy in ATC. In this study, we developed a novel high-throughput NIS enhancer screening platform using a dual repor...