Abstract. Lay CS, Agustina I, Astuti P, Hertiani T. 2023. Cytotoxic screening of endophytic fungi associated with Catharanthus roseus. Biodiversitas 24: 2716-2722. Despite the advancements in cancer therapy, there is still a need for new anticancer agents. Due to tremendous range chemical compounds that create, they have become crucial component current drug development process. The aim this st...

Imaging mass spectrometry (IMS) is a powerful technique that enables analysis of various molecular species at high spatial resolution with low detection limits. In contrast to the matrix-assisted laser desorption/ionization (MALDI-MS) approach, surface-assisted (SALDI) can be more effective in small molecules due absence interfering background signals m/z ranges. We developed functionalized TiO...

root ofplumbago indica linn is used in ayurveda and siddha medicine for the treatment of colic inflammations bronchitis, helminthiasis, hemorrhoids, elephantiasis, hepatosplenomegaly, amenorrhea, odontalgia, piles, and diabetes. the present study aims to investigate the anatomical characters of thin and thick root and to confirm the physicochemical characters of the root. anatomical studies and...

We have found that coupling between catharanthine and vindoline occurs non-enzymatically in the presence of flavin mononucleotide and manganese ions with near-ultraviolet light irradiation in vitro. The present study found that the concentrations of catharanthine and vindoline in Catharanthus roseus decreased and those of dimeric indole alkaloids increased under near-ultraviolet light at 4 degr...

In this study, three semisynthetic betulonic acid-based compounds, 20(29)-dihydrolup-2-en[2,3-d]isoxazol-28-oic acid, 1-betulonoylpyrrolidine, and lupa-2,20(29)-dieno[2,3-b]pyrazin-28-oic acid, were studied in biotransformation experiments using Nicotiana tabacum and Catharanthus roseus cell suspension cultures. Biotransformation was performed using cyclodextrin to aid dissolving poorly water-s...

Catharanthus roseus is widely cultivated around the world.  Cold atmosphere plasma (CAP) has been used to improve crop plants seed germination, and plant growth. In the present study, three different times of CAP (40, 50 and 60s) were used for the treatment of C. roseus seeds, and the changes in morphological traits, antioxidant enzymes and the genetic content of the treated plants were examine...

Plants provide long-term and sustainable solutions to mitigate particulate matter (PM) pollution in urban environments. We evaluated total, fine, coarse large particle trapping abilities of an equal number common trees (Carica papaya, Citrus limon, Moringa oleifera, Ozoroa paniculosa, Peltophorum africanum, Psidium guajava) herbaceous species (Argemone ochroleuca, Catharanthus roseus, Gomphocar...

While this Article was undergoing peer review, Salim et al. (2013), Asada et al. (2013) and Salim et al. (2014) published individual steps of the (seco)iridoid biosynthesis pathway in Catharanthus roseus, including the molecular and biochemical characterization of 7-deoxyloganic acid hydroxylase, 7-deoxyloganetic acid glucosyl transferase and 7-deoxyloganetic acid synthase, which are in agreeme...

Arabinogalactan protein (AGP), a class of cell wall proteoglycan, was isolated from the hairy root cultures of a newly developed hairy root line IIT-BT/D1 of Catharanthus roseus (L.) G. Don. AGP was found to be present both in the roots (0.3 mg/g fresh weight) and in the spent media (47 mg/L). The compositional analysis revealed the predominance of arabinose and galactose sugar, a characteristi...