Transcatheter device closure of secundum atrial septal defect is a well known option since 1974. The procedure is routinely performed through femoral vein approach but rarely inferior venacava (IVC) may be interrupted or blocked so transfemoral approach cannot be an option in these patients. In such rare cases surgical closure can be performed but in cases of percutaneous closure of secundum at...

1920x1200 abstract: background: down syndrome is the most common chromosomal abnormality due to 21 trisomy that usually is accompany with congenital heart diseases. about fifty present of children with down syndrome have heart defects. this study was designed for the aim of abundance percents of septal heart defects in children with down syndrome at imam reza and imam ali hospitals in kermansha...

BACKGROUND The right-to-left shunt at the atrial level is responsible for arterial hypoxemia in patients with atrial septal defect. OBJECTIVES This study investigated the mechanism of arterial hypoxemia in patients with atrial septal defect by measuring the P(O2) in both the right and left upper pulmonary veins. SUBJECTS AND METHOD We prospectively measured the P(O2) in the femoral artery a...

Conduction time from the region of the sinus node to the region of the atrioventricular (A-V) node was studied during open heart surgery in 13 patients with an endocardial cushion type atrial septal defect, eight patients with a secundum type atrial septal defect, one patient with a sinus venosus type atrial septal defect, and eight patients with an intact atrial septum. Internodal conduction t...

Background—Mutations of the transcription factor Nkx2-5 cause pleiotropic heart defects with incomplete penetrance. This variability suggests that additional factors can affect or prevent the mutant phenotype. We assess here the role of genetic modifiers and their interactions. Methods and Results—Heterozygous Nkx2-5 knockout mice in the inbred strain background C57Bl/6 frequently have atrial a...

Isolated secundum atrial septal defect is one of the most common congenital heart defects. Surgical closure is the treatment of choice but is associated with a chest scar, some morbidity and a relatively long recovery and the use of cardiopulmonary bypass. Transcatheter closure of secundum atrial septal defect is therefore an attractive approach. 3 children, aged 5-10 years, underwent successfu...

Endocardial cushion defects are complex mal-formations with a wide clinical spectrum. The abnormalities range from a small defect of the atrial septum in the position of the ostium primum, with an abnormal cleft mitral valve, to more extensive abnormalities which include tricuspid incompetence and defects of the ventricular septum. In the most severe form a common atrioventricular canal occurs....

BACKGROUND Mutations of the transcription factor Nkx2-5 cause pleiotropic heart defects with incomplete penetrance. This variability suggests that additional factors can affect or prevent the mutant phenotype. We assess here the role of genetic modifiers and their interactions. METHODS AND RESULTS Heterozygous Nkx2-5 knockout mice in the inbred strain background C57Bl/6 frequently have atrial...