Micellar electrokinetic chromatography (MEKC), one of the major capillary electrophoresis (CE) modes, has been interfaced to mass spectrometry (MS) to provide high sensitivity and selectivity for analysis of chiral compounds. The research in this dissertation presents the development of novel polymeric glucopyranoside based molecular micelles (MoMs) (aka. polymeric surfactants) and their applic...

•Unique axial-to-axial chirality transfer for C–N axial construction•Ability to assemble two vicinal and remote stereogenic axes•Step-economic scalable synthesis of enantioenriched phenanthridinones•Broad scope, good yields, excellent enantioselectivities Axial widely exists in bioactive natural products, pharmaceuticals, chiral materials, ligands catalysts asymmetric catalysis. As such, the ef...

In this issue of Chem, Morandi and coworkers report an exciting reversible transfer hydroarylation between ketones unstrained arylated alcohols. Through a Rh-catalyzed β-aryl elimination process, the aryl moiety “shuttles” from alcohol to ketone substrate, which provides milder alternative conventional Grignard organolithium addition chemistry. The increasing need modify or derivatize complex o...

The thermodynamic constants of oxygen binding to cobalt “picket fence” porphyrin complexes, meso-tetra(a,o,a,oo-pivalamidophenyl)porphyrinatocobalt(II)1 -methylimidazole and 1,2-dimethylimidazole, are reported. In contrast to previously studied cobalt porphyrins, these complexes bind oxygen with the same affinity as cobalt substituted myoglobin and hemoglobin. Solvation effects are discussed as...

In this issue of Chem, Zhou and co-workers report a new strategy for synthesizing optically active N–C axially chiral compounds. the presence norbornene-ester-Pd catalyst, Catellani reaction iodobenzene derivatives with N-(2-substituted-phenyl)-2-bromobenzamides proceeds in highly enantioselective manner to give N-aryl-phenanthridinone derivatives. Atropisomeric biaryl C–C axis have been widely...

•Enantiotopic differentiation of dinitrile to all-carbon quaternary centers•Atom economic synthesis enantioenriched densely substituted pyridines•Zinc-promoted hetero-cyclometallation nickel with alkyne and nitrile•Broad scope, good enantioselectivity, excellent regioselectivity Pyridines are among the most significant heterocycles not only prevalently found in pharmaceuticals, natural products...