It has been suggested that the favorable side-effect profiles of atypical antipsychotics (e.g. clozapine and amisulpride) are related to their ∼100-fold faster dissociation from dopamine D2 receptors (D2R) compared with typical antipsychotics (e.g. haloperidol and chlorpromazine). Fast dissociation would entail rapidly reversible antagonism; however, this has not been thoroughly studied using f...

In this review report, an attempt made to present overview of schizophrenia & those drugs which are used in treatment psychiatric disorders as well some treatments for psychosis. 1908, the word was coined by Eugen Bleuler (Swiss psychiatrist). The use antipsychotics medication began from 1933 France. Laborit and Huguenard administrated aliphatic Phenothiazine, Chlorpromazine during surgery ...

OBJECTIVE To review, firstly, published studies comparing classic antipsychotics, benzodiazepines, and/or combination of both; and secondly, available data on the use of atypical antipsychotic medications in controlling agitation and aggressive behaviour seen in psychiatric patients in emergency. METHOD In the first review, studies comparing antipsychotics, benzodiazepines, and combination of...

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STUDY OBJECTIVE To quantify the risk of diabetes mellitus associated with atypical antipsychotics compared with conventional antipsychotics in managed care Medicaid patients with bipolar disorder. DESIGN Retrospective nested case-control study. DATA SOURCE Integrated seven-state Medicaid managed care claims database from January 1, 1998-December 31, 2002. PATIENTS Two hundred eighty-three...

The use of atypical antipsychotics in treatment of psychiatric diseases is getting more widespread every day. These drugs are called atypical because they provide improvement not only in the positive symptoms, but also in negative symptoms. Also, they have less adverse effects on the extrapyramidal system and tardive dyskinesia, and they do not cause hyperprolactinemia (Stahl 2008). All atypica...